Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia.
|
30598629 |
2018 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
We evaluated the effect of resveratrol and prednisolone on DNA methylation patterns of MDR1 gene promoter in the CCRF-CEM cell line as a representative for acute lymphoblastic leukemia.
|
29377275 |
2018 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia.
|
27960630 |
2017 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95% CI = 0.46-0.95, P = 0.026; TT vs.
|
24142546 |
2014 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia.
|
22674224 |
2012 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with acute lymphoblastic leukemia?
|
23244145 |
2012 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy individuals.
|
19317599 |
2008 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemia cell lines with t(17;19) and E2A-HLF expression.
|
16206189 |
2006 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased expression of multidrug resistance gene (MDR1) at relapse in a child with acute lymphoblastic leukemia.
|
16849280 |
2006 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia.
|
15717687 |
2005 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia.
|
15059065 |
2004 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia.
|
15547738 |
2004 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Activation of the MDR1 upstream promoter (USP) has been described previously in four lymphoblastic leukemia patients, where it is the major MDR1 promoter associated with P-glycoprotein overexpression.
|
15102684 |
2004 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Bone marrow aspirates from 30 children with a diagnosis of acute lymphoblastic leukemia were assessed for the expression of messenger RNA for the MDR-1, MRP and LRP genes by semi-quantitative RT-PCR.
|
15543372 |
2004 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
|
12851703 |
2003 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Resistance of bcr-abl-positive acute lymphoblastic leukemia to daunorubicin is not mediated by mdr1 gene expression.
|
12410571 |
2002 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.
|
12130511 |
2002 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia.
|
11964305 |
2002 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In order to identify genomic changes associated with drug-resistance acquisition, we performed R-banding karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization to compare a human T-cell lymphoblastic leukemia cell line, CEM-wild type, and a subline with resistance to vinblastine (CEM-VLB) and overexpressing P-glycoprotein.
|
11801309 |
2002 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, both AML and acute lymphoblastic leukemia patients with high MDR1 mRNA expression at diagnosis tended to show a low remission rate and short remission periods.
|
12028995 |
2002 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significance of MDR1, MRP1, GSTpi and GSTmu mRNA expression in acute lymphoblastic leukemia in Indian patients.
|
11323101 |
2001 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A similar strong association has been observed between the expression of P-glycoprotein and outcome of treatment in certain malignancies in children, such as neuroblastoma, rhabdomyosarcoma, and acute lymphoblastic leukemia.
|
7642465 |
1995 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
With respect to the negative controls, MCF7 and HL-60 cell lines, increased GST pi and mdr1 mRNA levels, expressed as arbitrary units (U), were respectively detected both in AML and in ALL patients.
|
7910222 |
1994 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the frequency and the prognostic value of different mechanisms of drug resistance in acute leukemias, we investigated the expression of mdr1 by immunocytochemistry, mRNA slot blot or RT-PCR in 182 cases of adult acute myeloid and 37 cases of adult lymphoblastic leukemia.
|
8075575 |
1994 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We studied the mdr1 gene expression in 36 freshly established cell lines from 28 children with acute lymphoblastic leukemia (16 T-ALL, six BCP-ALL, two B-ALL (L3), two biphenotypic leukemias, two Burkitt's lymphomas).
|
7905944 |
1994 |