PHB, prohibitin, 5245

N. diseases: 177; N. variants: 8
Disease: Malignant neoplasm of liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 AlteredExpression disease BEFREE The low expression of PHB1 located in the nucleus of liver cancer cells inhibits the proliferation and metastasis of liver cancer; thus, PHB1 exhibits the function of a tumor suppressor gene. 31558419 2020
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 Biomarker disease BEFREE The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. 30523154 2019
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 GeneticVariation disease BEFREE When the mice express PHB mutated on tyrosine-114 in adipocytes and macrophages, both males and females are still obese, but none develops liver cancer; instead, males develop lymph node tumors. 28399645 2017
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 Biomarker disease BEFREE Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells. 27981602 2017