Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>SERPINA1</i> gene and AAT protein play an active role in the pathogenesis of lung cancer and not just reflect inflammatory reaction related to cancer development.
|
31487965 |
2019 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we believe that proteins like α2 macroglobulin, αmicroglobulin/bikunin, and SERPINA1 could be useful biomarkers for early detection of lung cancer and in monitoring its evolution.
|
31180588 |
2019 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.
|
28368395 |
2017 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim is to know if AAT-deficient carriers have a higher risk of lung cancer in a study performed exclusively in never-smokers.
|
26287318 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
|
22993338 |
2012 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this case-control study was to investigate phenotypes and serum level of AAT in LC.
|
22331720 |
2012 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer.
|
22507634 |
2012 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Non-MM variants of AAT and ELA2 genotypes with predicted intermediate or high activity could also represent a risk factor for aggressive form of lung cancer associated with extrathoracic metastases.
|
20521180 |
2011 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the association between alpha 1-antitrypsin deficiency (α₁ATD) carriers and lung cancer risk has been found, the effects of α₁ATD carriers and serum alpha 1-antitrypsin (α₁AT) concentration on non-small cell lung cancer (NSCLC) survival remained unclear.
|
21173712 |
2011 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP1A1 haplotypes (in allele order CYP1A1*4, CYP1A1*2C, CYP1A1*2A) CGC and CGT were associated with an increased risk of lung cancer, whereas AAT was associated with decreased lung cancer risk in this population.
|
19608585 |
2010 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to test the relationship between alpha1-AT deficient genotypes S and Z and lung cancer in Jordanian lung cancer patients.
|
16501672 |
2006 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lung represents an attractive target organ for somatic gene therapy strategy in that, (1) it is easily accessible by vectors, (2) most frequent hereditary disorders, cystic fibrosis (CF) and alpha1-antitrypsin deficiency (alpha1AT), occur in the lung, and (3) carcinoma of the lung is apparently a most common cause of death in humans.
|
11899243 |
2001 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interaction was examined between smoking and each of four factors previously found to be related to AO: alpha-1 antitrypsin (PiZ allele), ABO blood groups (A antigen), ABH non-secretor status, and first degree relationship to a COPD or lung cancer patient.
|
3485586 |
1986 |