Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The aims of this study were to develop original mouse models of patient-derived primary GC orthotopic xenografts (PDOX) allowing the development of distant metastases as preclinical models to study the anti-metastatic efficiency of drugs such as the phosphatidylinositol 3-kinase (PI3K) inhibitor Buparlisib (BKM120).
|
31010193 |
2019 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Analysis of KRAS, NRAS, BRAF, and PIK3CA mutations could predict metastases in colorectal cancer: A preliminary study.
|
30085422 |
2019 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
KRAS, PIK3CA and TP53 mutations were associated with distant metastases and a poor prognosis.
|
30867754 |
2019 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, oxidative stress inhibited HER2-or PI3K-mediated tumor metastasis via the MST2-FoxO3a-ΔNp63α pathway.
|
31212215 |
2019 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The elevated expression of TGF-β1 increases the PI3K/AkT/mTOR activity in human breast cancer tissue and potentially motivates tumor metastasis and resistance to chemotherapy.
|
31313132 |
2019 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Stage I-III patients with PIK3CA or NRAS mutations developed more distant metastases (3-year risk in PIK3CA mutated and wild type patients: 23.3% vs 11.5%, P = 0.03; multivariate Hazard ratio (HR) = 3.129, P = 0.003; 3-year risk in NRAS mutated and wild type patients: 40.0% vs 12.2%, P = 0.012; multivariate HR = 5.152, P = 0.003).
|
29666387 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Further analysis showed that PI3K/AKT signaling is altered in both the primary and metastases of NSCLC patients with brain lesions.
|
29899834 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these findings suggest that AnnexinA5 or the PI3K/Akt/NF-κB pathway may be promising therapeutic molecules to eradicate glioma metastases.
|
29520611 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program in laryngeal cancer.What is already known about this subject?• Cancer of the larynx is one of the most common types of head and neck cancer.• The survival rate of advanced laryngeal cancer is only 30 to 40%.• The tropomyosin-related kinase B receptor (TrkB), together with TrkA and TrkC, are neurotrophin receptors regulating the proliferation and differentiation of neuronal cells.What are the new findings?• TrkB are overexpressed in laryngeal cancer.• TrkB signaling is involved in tumorigenicity of laryngeal cancer.• TrkB acts as a key regulator of the PI3K/AKT signal pathway-mediated tumor metastasis.How might these results change the focus of research or clinical practice?• These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program in laryngeal cancer.
|
29312563 |
2017 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor genomic complexity increases with EGFR-inhibitor treatment, and co-occurring alterations in CTNNB1 and PIK3CA exhibit nonredundant functions that cooperatively promote tumor metastasis or limit EGFR-inhibitor response.
|
29106415 |
2017 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.
|
28860563 |
2017 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Displacement loop instability occurred significantly more frequently in lymph node metastases and distant metastases of patients with early colorectal cancer onset age <60 years ( p = 0.0122 and p = 0.0129), was found with a significant high rate in a small cohort of TP53-mutated distant metastases ( p = 0.0418), and was associated with TP53 wild-type status of primary tumors ( p = 0.0009), but did not correlate with KRAS, NRAS, BRAF, or PIK3CA mutations.
|
28345467 |
2017 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis.
|
28468801 |
2017 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The apoptosis associated protein (caspase-3, PARP,Bax,Bcl-2 and survivin) and metastases associated proteins including HEF1, MMP9 and VEGF were detected by Western blot, and the same method was used in the expression of PI3K and Akt.
|
28468627 |
2017 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Using comprehensive multi-omic molecular profiling, we assessed whether alterations or activation of the PI3K-AKT-mTOR pathway is associated with specific sites of breast cancer metastasis.<b>Experimental Design:</b> Next-generation sequencing-based whole-exome sequencing was coupled with reverse-phase protein microarray (RPPA) functional signaling network analysis to explore the PI3K-AKT-mTOR axis in 32 pretreated breast cancer metastases.
|
28446508 |
2017 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, we also demonstrated that patients with their primary RCC overexpressing 2 or more MCM genes had a shorter disease-free survival time, while those with RCC metastases overexpressing 3 or more MCM genes had a shorter disease-free survival.
|
29180899 |
2017 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
5-Azacytidine promotes invadopodia formation and tumor metastasis through the upregulation of PI3K in ovarian cancer cells.
|
28947962 |
2017 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Circular and linear expression exhibits an inverse trend for many cancer related pathways and signaling pathways like NFkB, PI3k/AKT and TGF-β typically activated for mRNA in metastases are inhibited for circRNA expression.
|
27119352 |
2016 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, detection of the changes in expression levels of metastasis‑associated gene 1 (MTA‑1) and tumor metastasis suppressor gene, non‑metastasis protein 23‑H1 (nm23‑H1), and the expression change of autophagy‑associated signal transduction pathway, phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (PKB) kinase were analyzed.
|
27082164 |
2016 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
|
27628214 |
2016 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AGS cells with CLEC2 knockdown had increased levels of phosphorylated AKT and glycogen synthase kinase-3 beta, increased expression of Snail, reduced levels of E-cadherin, and formed more metastases in mice than AGS cells that expressed CLEC2; these knockdown changes were prevented by the PI3K inhibitor LY294002.
|
26855187 |
2016 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
KRAS, BRAF and PIK3CA mutations are highly concordant between primary tumors and corresponding metastases in CRC, but PTEN loss is not.
|
25639985 |
2015 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
PIK3CA mutations were significantly associated with less distant metastases (mutant-type: 8/105, wild-type: 98/666, p = 0.048).
|
26358014 |
2015 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The primary rectal cancer and the matched metastases (hepatic, pulmonary and lymph nodal) demonstrated no KRAS, NRAS, BRAF and PIK3CA mutations, a microsatellite stable phenotype, and no tumor protein p53 alterations or recurrent copy number alterations on chromosome 8.
|
26231173 |
2015 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Together, these results demonstrate that HGF/c-met can activate PI3K/Akt and downstream NF-κB signaling to promote HPA expression and subsequent tumor metastasis.
|
25727320 |
2015 |