|
Malignant neoplasm of breast
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In line with this notion, we found that PML is associated to the promoter regions of MYC and PIM1, consistent with their direct correlation in breast cancer specimens.
|
31570853 |
2020 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
This study proposed the upregulation of PIM1 by IL-6 contributed to breast cancer cell aggressiveness and targeting PIM1 or c-myc could be novel approaches for breast cancer treatment.
|
30989585 |
2019 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
Oncogene <i>PIM-1</i> was found to be upregulated in breast cancer, especially in triple-negative breast cancer.
|
31496730 |
2019 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
Combined inhibition of PIM and PI3K may therefore be warranted in a subset of breast cancers.Cancer Discov; 6(10); 1134-47.
|
27604488 |
2016 |
|
Malignant neoplasm of breast
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Small-molecule PIM kinase inhibitors halted the growth of human TN tumors with elevated MYC expression in patient-derived tumor xenograft (PDX) and MYC-driven transgenic mouse models of breast cancer by inhibiting the oncogenic transcriptional activity of MYC and restoring the function of the endogenous cell cycle inhibitor, p27.
|
27775705 |
2016 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
This novel miR-486-5p/PIM-1 axis provides insight into the pathogenesis of BC and might be therapeutic targets for prevention or treatment of BC.
|
25104088 |
2014 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
In sum, identification of PIM-1 as an ERα target gene adds a novel potential mechanism by which estrogens can contribute to breast cancer cell proliferation and carcinogenesis.
|
23142699 |
2013 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Breast Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In line with this notion, we found that PML is associated to the promoter regions of MYC and PIM1, consistent with their direct correlation in breast cancer specimens.
|
31570853 |
2020 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
This study proposed the upregulation of PIM1 by IL-6 contributed to breast cancer cell aggressiveness and targeting PIM1 or c-myc could be novel approaches for breast cancer treatment.
|
30989585 |
2019 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
Oncogene <i>PIM-1</i> was found to be upregulated in breast cancer, especially in triple-negative breast cancer.
|
31496730 |
2019 |
|
Breast Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Small-molecule PIM kinase inhibitors halted the growth of human TN tumors with elevated MYC expression in patient-derived tumor xenograft (PDX) and MYC-driven transgenic mouse models of breast cancer by inhibiting the oncogenic transcriptional activity of MYC and restoring the function of the endogenous cell cycle inhibitor, p27.
|
27775705 |
2016 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
This novel miR-486-5p/PIM-1 axis provides insight into the pathogenesis of BC and might be therapeutic targets for prevention or treatment of BC.
|
25104088 |
2014 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
In sum, identification of PIM-1 as an ERα target gene adds a novel potential mechanism by which estrogens can contribute to breast cancer cell proliferation and carcinogenesis.
|
23142699 |
2013 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Glioblastoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Globally, our data represent the first evidence that PIM kinases regulate TRAIL-induced apoptosis in GBM and identify a specific role of p62/SQSTM1<sup>Ser332</sup> phosphorylation in the regulation of the extrinsic apoptosis pathway activated by TRAIL.
|
30718520 |
2019 |
|
Glioblastoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our data indicate that PIM1 inhibition and ABT-737 synergistically induce apoptosis in an MCL1-independent but CASP8-dependent manner in GB.
|
30389373 |
2019 |
|
Glioblastoma Multiforme
|
0.330 |
Biomarker
|
disease |
BEFREE |
Globally, our data represent the first evidence that PIM kinases regulate TRAIL-induced apoptosis in GBM and identify a specific role of p62/SQSTM1<sup>Ser332</sup> phosphorylation in the regulation of the extrinsic apoptosis pathway activated by TRAIL.
|
30718520 |
2019 |
|
Glioblastoma Multiforme
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our data indicate that PIM1 inhibition and ABT-737 synergistically induce apoptosis in an MCL1-independent but CASP8-dependent manner in GB.
|
30389373 |
2019 |
|
Glioblastoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
We conclude that U1i represents an alternative to RNAi for the therapeutic silencing of pathologically upregulated genes and demonstrate the functional relevance of Pim-1 oncogene knockdown in glioblastoma.
|
23724780 |
2013 |
|
Glioblastoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
We conclude that U1i represents an alternative to RNAi for the therapeutic silencing of pathologically upregulated genes and demonstrate the functional relevance of Pim-1 oncogene knockdown in glioblastoma.
|
23724780 |
2013 |
|
Glioblastoma Multiforme
|
0.330 |
Biomarker
|
disease |
BEFREE |
We conclude that U1i represents an alternative to RNAi for the therapeutic silencing of pathologically upregulated genes and demonstrate the functional relevance of Pim-1 oncogene knockdown in glioblastoma.
|
23724780 |
2013 |
|
Glioblastoma Multiforme
|
0.330 |
Biomarker
|
disease |
CTD_human |
We conclude that U1i represents an alternative to RNAi for the therapeutic silencing of pathologically upregulated genes and demonstrate the functional relevance of Pim-1 oncogene knockdown in glioblastoma.
|
23724780 |
2013 |
|
Mammary Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
|
27775705 |
2016 |
|
Prostatic Intraepithelial Neoplasias
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
PIM1 kinase is overexpressed in high-grade prostate intraepithelial neoplasia and in prostate cancer compared to normal prostatic tissue and benign prostate hyperplasia.
|
24274399 |
2014 |