leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The residues of the bottom group (Gln127, Asp128, and Leu174 in Pim1) were crucial for Pims/PIM447 systems, while the contributions of these residues were decreased sharply for Pims/AZD1208 systems.
|
31671637 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
For different GB cell lines, Western Blot, mitochondrial fractionation, fluorescence microscopy, effector caspase assays, flow cytometry, and an adult organotypic brain slice transplantation model were used to investigate the putative PIM1/MCL1 signaling axis regarding potential synergistic effects with ABT-737.
|
30389373 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
PIM-1 kinase is an important target in effective therapeutic interventions of lymphomas, prostate cancer and leukemia.
|
30895980 |
2019 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overall, our results demonstrate that STAT5, in part by upregulating PIM1 activity, plays a major role in mediating the leukemia-promoting effects of IL-7/IL-7R.
|
30185437 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sotrastaurin decreased the expression of pro-survival protein myeloid cell leukemia (MCL-1) and the phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), both of which are downstream effectors of PIM-1.
|
30017192 |
2018 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The three PIM kinase isozymes (PIM1, PIM2, and PIM3) share similar downstream substrates with other key oncogenic kinases and have differing but mutually compensatory functions across tumors.
|
29927999 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proviral Integration site for Moloney murine leukemia virus-1 (PIM1) belongs to the serine/threonine kinase family of Ca<sup>2+</sup>-calmodulin-dependent protein kinase (CAMK) group, which is involved in cell survival and proliferation as well as a number of other signal transduction pathways.
|
29635214 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these studies indicate that targeting STAT5 or STAT5-regulated pathways may provide a new approach for therapy development in Ph+ ALL, especially the relapsed/TKI-resistant disease.<b>Significance:</b> Suppression of STAT5 by BCL2 and PIM kinase inhibitors reduces leukemia burden in mice and constitutes a new potential therapeutic approach against Ph+ ALL, especially in tyrosine kinase inhibitor-resistant disease.<i></i>.
|
30154155 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Provirus integration site for Moloney murine leukemia virus 1 (Pim-1) has proved to be an oncogene and it is known that to depress Pim-1 activity may be a novel oncological treatment strategy.
|
28228352 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
High expression of proviral integration site for Moloney murine leukemia virus-1 (PIM-1), a serine/threonine kinase, is associated with many cancers.
|
28851457 |
2017 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, CD95-mediated apoptosis induces Pim-1 down-regulation in BL B-cells, but Pim-1 down-regulation cannot fully eradicate BL and leukaemia.
|
27641442 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study suggests that PIM1 could be a valuable prognostic marker in patients with OS, and the biological functions of PIM kinase family in the osteosarcoma cell lines indicate that they could serve as potential therapeutic targets for OS.
|
27826617 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether these findings suggest that pharmacological PIM targeting may provide a unique therapeutic approach for the treatment of Ph+ leukemias.
|
26375673 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similar to the other Pim kinases (Pim-1 and Pim-2), Pim-3 is involved in many cellular processes, including cell proliferation, survival, and protein synthesis.
|
25071334 |
2014 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pim1 and the RAS pathway are potential therapeutic targets of these high-risk leukemias.
|
23974202 |
2013 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of Pim1 kinase were first discovered in human leukemia and lymphomas.
|
23565217 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
SGI-1776 is a small molecule and Pim kinase inhibitor with selectivity for Pim-1.
|
22955922 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability.
|
21474815 |
2011 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting Pim-1 with monoclonal antibody could be explored for the treatment of leukemia and may represent a novel strategy to overcome drug resistance.
|
19703513 |
2009 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The bcr-abl/M-induced tumors also showed recurring proviral integration near c-myc, Pim-1 and Mlvi-1, albeit at a lower frequency than seen in the Mo-MuLV tumors.
|
9204986 |
1997 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results imply a physiological role of the pim-1 protooncogene during hematopoietic development and a deregulation in various leukemias.
|
2682662 |
1989 |