PI4KA, phosphatidylinositol 4-kinase alpha, 5297

N. diseases: 31; N. variants: 9
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE We demonstrated that HCV hijacks hCKα to bridge PI4KIIIα and NS5A, forming a ternary complex, which then stimulates PI4KIIIα activity to produce PI4P. 28566381 2017
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE We conclude that Ser-235 phosphorylation of NS5A is essential for HCV RNA replication and normal replication complex formation and is regulated by PI4KIIIα. 26874015 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE However, DCV impairs late steps in PI4KA activation that requires NS5A expressed in the context of the HCV polyprotein. 25546252 2015
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE Also, phosphatidylinositol 4-kinase type IIIα (PI4KA) is necessary for the propagation of the hepatitis C virus, a major etiological factor for HCC. 24393405 2014
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE These studies highlight the risks of targeting PI4KA as an anti-hepatitis C virus strategy and also point to important distinctions between genetic and pharmacological studies when selecting host factors as putative therapeutic targets. 24415756 2014
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE Interference of the protein interaction between NS5A and PI4KIIIα decreased HCV propagation. 21297162 2011
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 19376974 2009
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 Biomarker disease BEFREE Using transient siRNA oligonucleotide transfections and stable shRNA knockdown clones in HuH-7 cells, the PI4KA gene was shown to be essential for the replication of all HCV genotypes tested (1a, 1b and 2a) but not required for bovine viral diarrhea virus (BVDV) RNA replication. 19304308 2009