|
Testicular Germ Cell Tumor
|
0.410 |
Biomarker
|
disease |
CTD_human |
Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation.
|
23666240 |
2013 |
|
Radially deviated wrists
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Radially deviated wrists
|
0.400 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
|
|
|
|
Polydactyly
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous variants in the GLI3, ZRS/SHH, and PITX1 have been associated with autosomal dominant polydactyly, while homozygous variants in the ZNF141, IQCE, GLI1, and FAM92A have been associated with autosomal recessive polydactyly.
|
31115189 |
2019 |
|
Polydactyly
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
To date variants in four genes GLI3, ZNF141, MIPOL1 and PITX1 have been implicated in developing non-syndromic form of polydactyly.
|
28488682 |
2017 |
|
Polydactyly
|
0.330 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus.
|
23022097 |
2012 |
|
Polydactyly
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Analysis of DNA from additional individuals with isolated lower-limb malformations and higher-degree polydactyly identified a third individual with long-bone deficiency and preaxial polydactyly harboring a heterozygous 35 bp deletion in PITX1.
|
22258522 |
2012 |
|
Liver carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In sorafenib-treated tumor samples, we further found inhibition of PTP1B activity and up-regulation of the PITX1-p120RasGAP axis, suggesting that PTP1B inhibitor may be effective for the treatment of hepatocellular carcinoma.
|
26840794 |
2016 |
|
Liver carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Low levels of DAB2IP and PITX1 were detected mostly in a HCC subclass from patients with poor survival, indicating that these proteins control tumor aggressiveness.
|
21067840 |
2011 |
|
LAURIN-SANDROW SYNDROME
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The findings demonstrate that mutations in PITX1 can cause a broad spectrum of isolated lower-limb malformations including clubfoot, deficiency of long bones, and mirror-image polydactyly.
|
22258522 |
2012 |
|
LAURIN-SANDROW SYNDROME
|
0.310 |
ChromosomalRearrangement
|
disease |
ORPHANET |
The findings demonstrate that mutations in PITX1 can cause a broad spectrum of isolated lower-limb malformations including clubfoot, deficiency of long bones, and mirror-image polydactyly.
|
22258522 |
2012 |
|
Autistic Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
Association between SNPs and autism was only detected for PITX1.
|
18053270 |
2007 |
|
Autistic Disorder
|
0.310 |
Biomarker
|
disease |
CTD_human |
Association between SNPs and autism was only detected for PITX1.
|
18053270 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fisher's exact indicated the upregulation of circ-PITX1 was associated with patients' tumor size and World Health Organization grade.
|
31069865 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1.
|
31260797 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, high miR-1204 and low PITX1 expression was highly correlated with tumor size, lymph node metastasis, and the TNM stage in patients diagnosed with NSCLC.
|
30549141 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both PITX1 exon 3 and lincRNA C5orf66-AS1 were significantly higher methylated in tumor tissue than in normal adjacent tissue (NAT) (PITX1 exon 3: tumor tissue 58.1%, NAT: 31.7%, p<0.001; lincRNA C5orf66-AS1: tumor tissue: 27.4%, NAT: 18.9%, p<0.001).
|
29425237 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PITX1 has been identified as a potential tumor-suppressor gene in several malignant tumors.
|
29734189 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pituitary homeobox 1 (PITX1) functions as a tumor suppressor in hepatocarcinogenesis by regulating the expression level of Ras guanosine triphosphatase-activating protein.
|
26840794 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PITX1 expression may be involved in tumor progression and is a potential tumor suppressor gene and prognostic marker for cutaneous malignant melanoma.
|
27742032 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the PITX1 gene has been considered as a tumor suppressor gene in various human cancers.
|
23816528 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Paired‑like homeodomain 1 (PITX1), which has been identified as a tumor suppressor, was found to be downregulated in ccRCC tissues and identified as a target gene of miR‑886‑3p.
|
25190136 |
2014 |
|
Testicular Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
|
23666240 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
An association between the lack of PITX1 mRNA expression and higher tumor grade was observed.
|
17157953 |
2007 |