PLA2G2A, phospholipase A2 group IIA, 5320

N. diseases: 215; N. variants: 6
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.150 GeneticVariation disease BEFREE Therefore, we investigated if COX-2 -1195G > A, 12-LOX 261Arg > Gln and PLA2 c.349 + 191A > G polymorphisms were associated with risk and prognosis of CRC as well as possible interactions with the environmental factors on the risk of CRC in Northeast of China. 23715757 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.150 Biomarker disease BEFREE Archival paraffin-embedded CRC tissue samples were used to prepare tissue microarray blocks for immunohistochemical staining with PLA2. 19276398 2009
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.150 GeneticVariation disease BEFREE On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His), were associated with a decrease in CRC risk. 18992148 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.150 AlteredExpression disease BEFREE Secretory type II phospholipase A2 (PLA2G2A) expression status in colorectal carcinoma derived cell lines and in normal colonic mucosa. 9788445 1998
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.150 GeneticVariation disease BEFREE To test the hypothesis of a correlation between PLA2G2A gene alterations and human tumor development, we screened 14 patients with FAP and 20 patients with sporadic colorectal cancer for germline and somatic PLA2G2A gene mutations. 9272153 1997
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.150 CausalMutation disease CLINVAR