PLA2G2A, phospholipase A2 group IIA, 5320

N. diseases: 215; N. variants: 6
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.060 AlteredExpression disease BEFREE We support the notion that bluntness in niacin skin test might reflect abnormalities in membrane fatty acid composition, which could be induced by increased PLA2 enzyme activity, in vivo oxidative stress or lipid metabolism imbalance in SZ. 29077970 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.060 GeneticVariation disease BEFREE These data indicate that variants of PLA2 encoding genes are plausible candidates for increasing the susceptibility for schizophrenia. 17629734 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.060 Biomarker disease BEFREE They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. 16115752 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.060 Biomarker disease BEFREE Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia. 15999343 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.060 GeneticVariation disease BEFREE Phospholipase A(2) (PLA2) is a key enzyme of the phospholipid metabolism which shows alteration in schizophrenia. 12759552 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.060 Biomarker disease BEFREE [1995: Med Hypotheses 45:605-613] strongly support cPLA2 (PLA2G4A) and sPLA2 (PLA2G1B) as candidate genes for schizophrenia. 11353443 2001