PLA2G2A, phospholipase A2 group IIA, 5320

N. diseases: 215; N. variants: 6
Disease: Allergic bronchitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1260881
Disease: Allergic bronchitis
Allergic bronchitis 		0.010 Biomarker disease BEFREE We have previously shown that in rats, sPLA2 and cPLA2 play opposing roles in the pathophysiology of ovalbumin (OVA)-induced experimental allergic bronchitis (OVA-EAB), an asthma model: Upon disease induction sPLA2 expression and production of the broncho-constricting CysLTs are elevated, whereas cPLA2 expression and the broncho-dilating PGE2 production are suppressed. 24204651 2013