Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease BEFREE This meta-analysis showed that T allele of rs2227564 polymorphism in PLAU gene could increase the effects on risk of AD, and this result needs to be confirmed by further studies. 23813610 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease BEFREE We have evaluated variants in seven Aβ-degrading genes (ACE, ECE1, ECE2, IDE, MME, PLAU, and TF) for association with AD risk in the Genetic and Environmental Risk in Alzheimer's Disease Consortium 1 (GERAD1) cohort, and with three cognitive phenotypes in the Lothian Birth Cohort 1936 (LBC1936), using 128 and 121 SNPs, respectively. 22693153 2013
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease BEFREE Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits. 16967469 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease LHGDN distribution of four tagSNPs (rs2227562 in intron 5, rs2227564 in exon 6, rs2227571 in intron 9, and rs4065 in 3'UTR) in the PLAU gene in a large case-control study of Alzheimer's disease 16967469 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease BEFREE Our data support a role for PLAU_1 as an independent genetic risk factor for AD in the Italian population for those subjects who do not have the APOE-epsilon4 allele. 17174555 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease LHGDN role for PLAU _ 1 as an independent genetic risk factor for Alzheimer disease in the Italian population for those subjects who do not have the APOE-epsilon4 allele 17174555 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease BEFREE A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. 16825285 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease LHGDN Evidence of a genetic and functional involvement of a common PLAU variant into the pathogenesis of Alzheimer Disease. 16825285 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease BEFREE No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits. 15558716 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. 15631996 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. 15615772 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro. 15240745 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Urokinase-deficient mice fail to generate a type 2 immune response following schistosomal antigen challenge. 14688127 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 GeneticVariation disease LHGDN PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection. 12898287 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization. 12657615 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Urokinase-type plasminogen activator is required for the generation of a type 1 immune response to pulmonary Cryptococcus neoformans infection. 11777975 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. 11907112 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease BEFREE We interpret these observations as suggesting that uPA represents a possible candidate gene for the chromosome 10 familial AD locus. 12271474 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system. 10880388 2000
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model. 8621764 1996
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease MGD Physiological consequences of loss of plasminogen activator gene function in mice. 8133887 1994
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.580 Biomarker disease CTD_human
CUI: C1866423
Disease: Quebec platelet disorder
Quebec platelet disorder
0.550 GeneticVariation disease BEFREE QPD is the first bleeding disorder identified to be caused by a PLAU mutation and it is also the first bleeding disorder recognized to result from a gene copy number mutation. 21495923 2011
CUI: C1866423
Disease: Quebec platelet disorder
Quebec platelet disorder
0.550 GeneticVariation disease BEFREE Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. 20007542 2010
CUI: C1866423
Disease: Quebec platelet disorder
Quebec platelet disorder
0.550 AlteredExpression disease BEFREE Although QPD CD34(+) progenitors expressed normal amounts of uPA, their differentiation into megakaryocytes abnormally increased expression of the uPA gene but not the flanking genes for vinculin or calcium/calmodulin-dependent protein kinase IIgamma on chromosome 10. 19029443 2009