PLEK, pleckstrin, 5341

N. diseases: 83; N. variants: 6
Disease: Leukemia, T-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.020 Biomarker disease BEFREE Recently, the proto-oncogene TCL1 (T cell leukemia 1), with a previously unknown physiological function, was shown to interact with the Akt pleckstrin homology domain, enhancing Akt kinase activity; hence, it functions as an Akt kinase coactivator. 17360849 2007
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.020 GeneticVariation disease BEFREE Induction of AKT serine/threonine kinase activity is augmented by the T-cell leukemia-1 (TCL1) oncoprotein through a physical association requiring the AKT pleckstrin homology domain. 12009899 2002