An important contribution to higher levels of PTOV1 in prostate tumors is given by the frequent rate of gene amplifications, also found in other tumor types.
Analyses of tumor datasets show that <i>PTOV1</i> expression significantly correlated with prostate tumor grade, drug resistance (<i>CCNG2</i>) and self-renewal (<i>ALDH1A1, MYC</i>) markers.
Our previous study indicated that the transcriptional activity of RA receptor (RAR) is enhanced by association of MED25 with CREB-binding protein (CBP) through the PTOV domain, which is also present in prostate tumor over-expressed protein 1 (PTOV1).
These observations suggest that overexpression of PTOV1 can contribute to the proliferative status of prostate tumor cells and thus to their biological behavior.