PMCH, pro-melanin concentrating hormone, 5367

N. diseases: 57; N. variants: 0
Disease: Depressed mood ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 GeneticVariation phenotype BEFREE We studied the effects of MCH (100 and 200 ng) into the LC on coping-stress related behaviors associated with depression, using two different behavioral tests: the forced swimming test (FST) and the learned helplessness (LH). 31376444 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 AlteredExpression phenotype BEFREE We report here that following a 5-week exposure to repeated chronic mild stress (an ethologically relevant animal model of depression), C57Bl/6J mice have increased hippocampal gene expression of MCH receptor subtype 1 (MCHR1), the cognate melanin concentrating hormone receptor in mice. 16934771 2007