|
Gestational Diabetes
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that PANDER might be considered a new biomarker for GDM.
|
30982368 |
2019 |
|
Esophageal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
FAM3B promotes progression of oesophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.
|
30565387 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results provide new insights into the role of FAM3B in the progression of ESCC and suggest that FAM3B may be a promising molecular target and diagnostic marker for ESCC.
|
30565387 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the prospective association of FAM3B with metabolic disorders remains unclear.
|
29178453 |
2018 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
FAM3B expression was analyzed by quantitative PCR in tumor tissue clinical samples and prostate tumor cell lines.
|
29357840 |
2018 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We observed an increase in FAM3B expression in prostate tumor samples when compared to normal tissues.
|
29357840 |
2018 |
|
Metabolic Syndrome X
|
0.010 |
Biomarker
|
disease |
BEFREE |
In comparison with the non-MetS group, participants with MetS had an increased serum FAM3B at baseline (21.85 ng/mL [19.38, 24.17 ng/mL] vs 28.56 ng/mL [25.32, 38.10 ng/mL], P < 0.001).
|
29178453 |
2018 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, FAM3B may therefore serve as a novel therapeutic target for diabetes-related CVDs.
|
28536423 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers.
|
28161382 |
2017 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers.
|
28161382 |
2017 |
|
Impaired glucose tolerance
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of PANDER in mice induced glucose intolerance and impaired glucose-stimulated GLP-1 secretion Moreover, PANDER blocked insulin-induced GLP-1 secretion by inhibiting the insulin signalling-Wnt pathway and directly inhibited the cAMP/PKA pathway.
|
28549991 |
2017 |
|
Cognition Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our results revealed the high levels of complexities of gene actions and interactions associated with the Setd4/Cbr1-Fam3b/Mx2 region as well as their relationship with developmental cognitive deficits in DS.
|
26374847 |
2015 |
|
Impaired cognition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed the high levels of complexities of gene actions and interactions associated with the Setd4/Cbr1-Fam3b/Mx2 region as well as their relationship with developmental cognitive deficits in DS.
|
26374847 |
2015 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression of FAM3B-258 in human colorectal adenocarcinomas was positively correlated with Slug.
|
23059759 |
2013 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
|
23059759 |
2013 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
|
23059759 |
2013 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In obesity status, increased expression and secretion of FAM3B in pancreatic islets and liver may induce lipid accumulation in the liver via the induction of hepatic insulin resistance and lipogenesis.
|
23855304 |
2013 |
|
Varicella Zoster Virus Infection
|
0.010 |
Biomarker
|
group |
BEFREE |
ORF11 protein interacts with the ORF9 essential tegument protein in varicella-zoster virus infection.
|
23427162 |
2013 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that FAM3B was expressed in mouse colon, intestine, liver and lung tissues and multiple types of cell lines, including murine pancreatic β-cell (Min6), microglia (N9) and muscle cell (C2C12); human colon cancer cells (HCT8, HCT116, HT29), hepatocyte (HL-7702), hepatocellular carcinoma cell (SMMC-7721) and lung carcinoma cell (A549).
|
23246487 |
2013 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
|
23059759 |
2013 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
|
23059759 |
2013 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
PANDER may represent a potential therapeutic target for the treatment of fatty liver and insulin resistance.
|
21412813 |
2011 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
PANDER may represent a potential therapeutic target for the treatment of fatty liver and insulin resistance.
|
21412813 |
2011 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we over-expressed CLN3P in SH-SY5Y neuroblastoma cells and monitored the effects on PANDER-induced apoptosis.
|
16515873 |
2006 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we over-expressed CLN3P in SH-SY5Y neuroblastoma cells and monitored the effects on PANDER-induced apoptosis.
|
16515873 |
2006 |