SEPTIN4, septin 4, 5414

N. diseases: 48; N. variants: 4
Disease: estrogen receptor-negative breast cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4733092
Disease: estrogen receptor-negative breast cancer
estrogen receptor-negative breast cancer 		0.010 Biomarker disease BEFREE 1α,25(OH)<sub>2</sub>D<sub>3</sub> and MART-10, an analog of 1α,25(OH)<sub>2</sub>D<sub>3</sub>, effectively repressed VEGF-A-induced MCF-7 cell migration and invasion and other VEGF-A-induced effects on MCF-7 cells, with MART-10 being more potent than 1α,25(OH)<sub>2</sub>D<sub>3</sub> Conclusion: MART-10 can be deemed as a promising agent for prevention and treatment of metastasis of ER+ breast cancer with VEGF-A overexpression. 29970508 2018