POLB, DNA polymerase beta, 5423

N. diseases: 63; N. variants: 6
Disease: Esophageal carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.040 GeneticVariation disease BEFREE These results suggest that polβ gene with G648C mutation in surgically resected esophagus may be clinically useful for predicting responsiveness to chemotherapy in patients with EC. 26334617 2016
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.040 GeneticVariation disease BEFREE The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER. 26527528 2015
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.040 GeneticVariation disease BEFREE DNA polymerase beta promoter mutations affect gene transcription, translation and the sensitivity of esophageal cancer cells to cisplatin treatment. 23117284 2013
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.040 GeneticVariation disease BEFREE Non high-incidence area group: polbeta gene variation was detected in 5 of 25 esophageal carcinoma tissue specimens, and no variation was found in 25 corresponding adjacent normal tissue specimens. 16094698 2005