POLR2G, RNA polymerase II subunit G, 5436

N. diseases: 13; N. variants: 1
Disease: Kidney Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022665
Disease: Kidney Neoplasm
Kidney Neoplasm 		0.010 Biomarker disease BEFREE Introducing wild-type pVHL into human kidney tumor cell lines carrying endogenous mutant non-functional pVHL facilitates ubiquitylation and proteasomal degradation of hsRPB7, and decreases its nuclear accumulation. pVHL can also suppress hsRPB7-induced VEGF promoter transactivation, mRNA expression and VEGF protein secretion. 12912922 2003