|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Asc-1 protein and SNAT2 mRNA were decreased in schizophrenia in both regions.
|
18400471 |
2008 |
|
Schizophrenia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Asc-1 protein and SNAT2 mRNA were decreased in schizophrenia in both regions.
|
18400471 |
2008 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Selective up-regulation of system a transporter mRNA in diabetic liver.
|
11798158 |
2002 |
|
Sepsis
|
0.200 |
Biomarker
|
disease |
RGD |
Different alterations in rat intestinal glutamine transport during the progression of CLP- and LPS-induced sepsis.
|
20338592 |
2011 |
|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Differential molecular regulation of glutamate in kindling resistant rats.
|
21138736 |
2011 |
|
Fibromuscular Dysplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2.
|
27718336 |
2017 |
|
Fibromuscular Dysplasia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
FMD outbreaks due to SAT 2 have been reported in many African countries.
|
30462886 |
2019 |
|
Muscular Dystrophy, Facioscapulohumeral
|
0.020 |
Biomarker
|
disease |
BEFREE |
Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2.
|
27718336 |
2017 |
|
Muscular Dystrophy, Facioscapulohumeral
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
FMD outbreaks due to SAT 2 have been reported in many African countries.
|
30462886 |
2019 |
|
FRONTOMETAPHYSEAL DYSPLASIA 1
|
0.020 |
Biomarker
|
disease |
BEFREE |
Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2.
|
27718336 |
2017 |
|
FRONTOMETAPHYSEAL DYSPLASIA 1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
FMD outbreaks due to SAT 2 have been reported in many African countries.
|
30462886 |
2019 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
At the age of asthma onset, there was a low frequency of current smokers (9.7%), but a high frequency of past smokers (20.2%) in the AERD group compared with the ATA-1 (20.5% and 12.0% for current and past smokers, respectively), ATA-2 (24.5% and 10.3%, respectively), and HC group (26.2% and 12.6%, respectively).
|
28583479 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that the glutamine transporter, SNAT2, is the AA transporter most frequently induced by hypoxia in breast cancer, and is regulated by hypoxia both in vitro and in vivo in xenografts.
|
31152137 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Understanding the basis of such regulation is important given that AA uptake <i>via</i> SNAT2 has been linked to activation of mTORC1; a major controller of many important cellular processes including, for example, mRNA translation, lipid synthesis, and autophagy and whose dysregulation has been implicated in the development of cancer and conditions such as obesity and type 2 diabetes.
|
29467657 |
2018 |
|
Dwarfism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, transgenic rice plants in which SNAT2 expression were suppressed by RNAi technology showed a decrease in melatonin and a dwarf phenotype with erect leaves, reminiscent of brassinosteroids (BR)-deficient mutants.
|
29607549 |
2018 |
|
Hamartoma Syndrome, Multiple
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Several genes of growth factors, such as Vegf-a, placental growth factor, Igf1 and Igf1r, and several genes of nutrient transport pumps, such as Glut1, Fatp1 and Snat2, were down-regulated in placenta of Cd-treated mice.
|
29373603 |
2018 |
|
Hyperinsulinism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study investigated the benefit of adding glutamine to a regimen of liraglutide in diabetic rats focusing on their role in increasing insulin production and upregulation of the expression of sodium-dependent neutral aminoacid transporter-2 (SNAT2).
|
29475006 |
2018 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By qualitative and quantitative PCR, we evaluated the expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas).
|
17119850 |
2007 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We confirmed hypomethylation of both satellite α (Sat α) and satellite 2 (Sat 2) DNA in Wilms tumor samples compared with normal kidney.
|
23074036 |
2013 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Understanding the basis of such regulation is important given that AA uptake <i>via</i> SNAT2 has been linked to activation of mTORC1; a major controller of many important cellular processes including, for example, mRNA translation, lipid synthesis, and autophagy and whose dysregulation has been implicated in the development of cancer and conditions such as obesity and type 2 diabetes.
|
29467657 |
2018 |
|
Thromboangiitis Obliterans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, mRNA levels of sialyltransferase (SAT)-I and SAT II were increased in TAO patients compared with control.
|
20811057 |
2011 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that the glutamine transporter, SNAT2, is the AA transporter most frequently induced by hypoxia in breast cancer, and is regulated by hypoxia both in vitro and in vivo in xenografts.
|
31152137 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using both in vivo and in vitro models, we found that knocking down ASCT2 by shRNAs or miR-137 or the combination of silencing ASCT2 and pharmacologically inhibiting SNAT2 via a small-molecule antagonist called V-9302 significantly suppressed intracellular glutamine levels and downstream glutamine metabolism, including glutathione production; these effects attenuated growth and proliferation, increased apoptosis and autophagy, and increased oxidative stress and mTORC1 pathway suppression in HNSCC.
|
31819178 |
2020 |
|
Childhood Kidney Wilms Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
We confirmed hypomethylation of both satellite α (Sat α) and satellite 2 (Sat 2) DNA in Wilms tumor samples compared with normal kidney.
|
23074036 |
2013 |
|
Aspirin exacerbated respiratory disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
After adjustment for confounding variables, AERD was positively associated with smoking cessation between 1 and 4 years before disease onset compared with the ATA-2 group (adjusted odds ratio [aOR] 4.63, 95% confidence interval [CI]: 2.16-9.93) and the HC group (aOR 4.09, 95% CI: 2.07-8.05), implying that smoking cessation was followed by the development of AERD.
|
28583479 |
2019 |