Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET Asc-1 protein and SNAT2 mRNA were decreased in schizophrenia in both regions. 18400471 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 AlteredExpression disease BEFREE Asc-1 protein and SNAT2 mRNA were decreased in schizophrenia in both regions. 18400471 2008
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.210 AlteredExpression phenotype BEFREE In this study, we propose the hypothesis that JAK-STAT pathway genes are differentially expressed in idiopathic FGR-affected pregnancies and contribute to abnormal feto-placental growth by modulating the expression of the amino acid transporter SNAT2, differentiation marker CGB/human chorionic gonadotrophin beta-subunit (β-hCG) and apoptosis markers caspases 3 and 8, and TP53. 25713425 2015
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.210 Biomarker phenotype RGD Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport. 21812961 2011
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker disease RGD Different alterations in rat intestinal glutamine transport during the progression of CLP- and LPS-induced sepsis. 20338592 2011
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker disease RGD Differential molecular regulation of glutamate in kindling resistant rats. 21138736 2011
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Selective up-regulation of system a transporter mRNA in diabetic liver. 11798158 2002
CUI: C0016052
Disease: Fibromuscular Dysplasia
Fibromuscular Dysplasia 		0.020 GeneticVariation disease BEFREE FMD outbreaks due to SAT 2 have been reported in many African countries. 30462886 2019
CUI: C0238288
Disease: Muscular Dystrophy, Facioscapulohumeral
Muscular Dystrophy, Facioscapulohumeral 		0.020 GeneticVariation disease BEFREE FMD outbreaks due to SAT 2 have been reported in many African countries. 30462886 2019
CUI: C4281559
Disease: FRONTOMETAPHYSEAL DYSPLASIA 1
FRONTOMETAPHYSEAL DYSPLASIA 1 		0.020 GeneticVariation disease BEFREE FMD outbreaks due to SAT 2 have been reported in many African countries. 30462886 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 GeneticVariation group BEFREE Nodules were retrospectively reviewed, assigned a 2015 ATA morphology, and placed into one of five 2015 ATA categories of risk (ATA-1, <1% risk of malignancy; ATA-2, <3% risk; ATA-3, 5% to 10% risk, ATA-4: 10% to 20% risk; ATA-5, >70% to 90% risk) by a reader who was blinded to cytology. 29982716 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE Understanding the basis of such regulation is important given that AA uptake <i>via</i> SNAT2 has been linked to activation of mTORC1; a major controller of many important cellular processes including, for example, mRNA translation, lipid synthesis, and autophagy and whose dysregulation has been implicated in the development of cancer and conditions such as obesity and type 2 diabetes. 29467657 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE Understanding the basis of such regulation is important given that AA uptake <i>via</i> SNAT2 has been linked to activation of mTORC1; a major controller of many important cellular processes including, for example, mRNA translation, lipid synthesis, and autophagy and whose dysregulation has been implicated in the development of cancer and conditions such as obesity and type 2 diabetes. 29467657 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 GeneticVariation group BEFREE Nodules were retrospectively reviewed, assigned a 2015 ATA morphology, and placed into one of five 2015 ATA categories of risk (ATA-1, <1% risk of malignancy; ATA-2, <3% risk; ATA-3, 5% to 10% risk, ATA-4: 10% to 20% risk; ATA-5, >70% to 90% risk) by a reader who was blinded to cytology. 29982716 2018
CUI: C0016052
Disease: Fibromuscular Dysplasia
Fibromuscular Dysplasia 		0.020 Biomarker disease BEFREE Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2. 27718336 2017
CUI: C0238288
Disease: Muscular Dystrophy, Facioscapulohumeral
Muscular Dystrophy, Facioscapulohumeral 		0.020 Biomarker disease BEFREE Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2. 27718336 2017
CUI: C4281559
Disease: FRONTOMETAPHYSEAL DYSPLASIA 1
FRONTOMETAPHYSEAL DYSPLASIA 1 		0.020 Biomarker disease BEFREE Antigen ELISA of viral isolates was used to identify FMD virus serotypes O, A and SAT 2. 27718336 2017
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.010 AlteredExpression disease BEFREE Using both in vivo and in vitro models, we found that knocking down ASCT2 by shRNAs or miR-137 or the combination of silencing ASCT2 and pharmacologically inhibiting SNAT2 via a small-molecule antagonist called V-9302 significantly suppressed intracellular glutamine levels and downstream glutamine metabolism, including glutathione production; these effects attenuated growth and proliferation, increased apoptosis and autophagy, and increased oxidative stress and mTORC1 pathway suppression in HNSCC. 31819178 2020
CUI: C0004096
Disease: Asthma
Asthma 		0.010 GeneticVariation disease BEFREE At the age of asthma onset, there was a low frequency of current smokers (9.7%), but a high frequency of past smokers (20.2%) in the AERD group compared with the ATA-1 (20.5% and 12.0% for current and past smokers, respectively), ATA-2 (24.5% and 10.3%, respectively), and HC group (26.2% and 12.6%, respectively). 28583479 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 Biomarker disease BEFREE Here, we show that the glutamine transporter, SNAT2, is the AA transporter most frequently induced by hypoxia in breast cancer, and is regulated by hypoxia both in vitro and in vivo in xenografts. 31152137 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 Biomarker disease BEFREE Here, we show that the glutamine transporter, SNAT2, is the AA transporter most frequently induced by hypoxia in breast cancer, and is regulated by hypoxia both in vitro and in vivo in xenografts. 31152137 2019
CUI: C3853540
Disease: Aspirin exacerbated respiratory disease
Aspirin exacerbated respiratory disease 		0.010 Biomarker disease BEFREE After adjustment for confounding variables, AERD was positively associated with smoking cessation between 1 and 4 years before disease onset compared with the ATA-2 group (adjusted odds ratio [aOR] 4.63, 95% confidence interval [CI]: 2.16-9.93) and the HC group (aOR 4.09, 95% CI: 2.07-8.05), implying that smoking cessation was followed by the development of AERD. 28583479 2019
CUI: C4049259
Disease: Hormone refractory breast cancer
Hormone refractory breast cancer 		0.010 Biomarker disease BEFREE Development of drugs targeting SNAT2 may be of value for a subset of hormone-resistant breast cancer. 31152137 2019
CUI: C4285716
Disease: Melatonin deficiency
Melatonin deficiency 		0.010 GeneticVariation disease BEFREE In contrast, tryptamine 5-hydroxylase (T5H) knockout Sekiguchi rice and caffeic acid O-methyltransferase (COMT) RNAi rice seedlings were semidwarf phenotypes with erect leaves, as was the snat2 RNAi rice due to a melatonin deficiency. 30403303 2019
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 AlteredExpression disease BEFREE Understanding the basis of such regulation is important given that AA uptake <i>via</i> SNAT2 has been linked to activation of mTORC1; a major controller of many important cellular processes including, for example, mRNA translation, lipid synthesis, and autophagy and whose dysregulation has been implicated in the development of cancer and conditions such as obesity and type 2 diabetes. 29467657 2018