PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Male infertility ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 AlteredExpression phenotype BEFREE We speculate that the low activity of PON1 can be a risk factor for male infertility probably due to a decrease in antioxidant activity of PON1 and increase in lipid peroxidation. 25264968 2014
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 Biomarker phenotype CTD_human The results indicated that the PON1 Arg192Glu (rs662) and SOD2 Val16Ala (rs4880) variant genotypes were associated with a significantly higher risk of male infertility. 22206979 2012
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 GeneticVariation phenotype BEFREE The results indicated that the PON1 Arg192Glu (rs662) and SOD2 rs4880" genes_norm="6648;6649">Val16Ala (rs4880) variant genotypes were associated with a significantly higher risk of male infertility. 22206979 2012
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 Biomarker phenotype CTD_human However, no significant differences in genotype frequencies of other tested polymorphisms (PON1-192, PON2-311, GSTM1/T1) and male infertility were observed. 21561808 2011
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 GeneticVariation phenotype BEFREE Association between male infertility and genetic variability at the PON1/2 and GSTM1/T1 gene loci. 21561808 2011