PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.050 Biomarker disease BEFREE In SSc, anti-centromere antibodies correlated PON1 activity. anti-<i>Saccharomyces cerevisiae</i> antibodies levels were negatively associated with PON1 activity (<i>r</i> = -0.257, <i>p</i> = 0.012) and PON1/TAC ratio (<i>r</i> = -0.261, <i>p</i> = 0.009) in IBD/Crohn. 29740582 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.050 Biomarker disease BEFREE PON-1 as a marker for CD differentiation possessed a sensitivity and specificity of 93.62% and 91.30%, respectively. 30314292 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.050 Biomarker disease LHGDN PON1 was a poorer indicator of CD or UC than CRP. 18626964 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.050 Biomarker disease BEFREE Our results showed that significantly fewer biopsies expressed PON1 and PON3 in the duodenum of celiac patients (PON1, P<0.0001; PON3, P=0.03), in the terminal ileum of Crohn's patients (PON1, P=0.001; PON3, P=0.008), and in the colon of UC patients (PON1, P=0.02; PON3, P=0.06) compared to controls. 17664137 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.050 GeneticVariation disease BEFREE The paraoxonase (PON) genes family maps to chromosome 7q21-q22, within a loci that also showed evidence of susceptibility genes for both Crohn's disease (CD) and ulcerative colitis (UC). 17436100 2007