PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Age related macular degeneration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.060 AlteredExpression disease BEFREE At serum level, PON1 protein was significantly increased in AMD patients. 27693409 2016
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.060 GeneticVariation disease BEFREE We investigated association of DNA sequence variants (SNP) within the upstream regulatory region of the PON1 gene with neovascular AMD in 305 patients and 288 controls. 22956172 2013
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.060 GeneticVariation disease BEFREE The authors found that subjects with the PON1 MM and QQ genotypes had a lower risk of AMD. 23538572 2013
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.060 AlteredExpression disease BEFREE The aim of the present study was to investigate homocysteine (Hcy) level and antioxidant paraoxonase 1 (PON1) activity within its phenotypes together with oxidized low-density lipoprotein (OX-LDL) levels in the patients with exudative AMD. 22030834 2012
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.060 GeneticVariation disease BEFREE This study investigated whether PON1 gene polymorphisms associate with AMD. 20042177 2010
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.060 GeneticVariation disease BEFREE The M55L and Q192R SNPs of the PON1 gene do not appear to be associated with late AMD in individuals of Anglo-Celtic descent. 15488805 2004