PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.040 Biomarker disease BEFREE Paraoxonase-1 (PON1) is a serum-based antioxidant, anti-inflammatory agent, detoxifier, and quorum-sensing factor found to be a prognostic marker in sepsis. 30886652 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.040 Biomarker disease BEFREE These results highlight relationships between paraoxonase-1 and infectious diseases and sepsis, with insights into potential clinical evolution of treatment. 30165052 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.040 AlteredExpression disease BEFREE The aim of the study was to compare functional properties of HDL (cholesterol efflux capacity and paraoxonase enzyme 1 [PON-1] activity) and Dys-HDL between older (aged >65 years) sepsis patients and older healthy volunteers. 29049133 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.040 AlteredExpression disease BEFREE Persistently low PON1 activity in plasma was associated with lethal outcome in human and murine sepsis. 20221873 2010