DDIT4, DNA damage inducible transcript 4, 54541

N. diseases: 92; N. variants: 0
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.020 Biomarker disease BEFREE Intriguingly, REDD1 depression abrogated neuronal oxidative stress under OGD/R condition by suppressing ROS, MDA generation, and increasing antioxidant SOD levels. 31021470 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.020 AlteredExpression disease BEFREE Molecular studies identified lower levels of REDD1, a protein previously linked to depression, in the PFC of HET mice, and viral-mediated REDD1 overexpression in the PFC of these HET mice reversed the antidepressant-like effect in SPT and TST. 27922594 2017