DLL4, delta like canonical Notch ligand 4, 54567

N. diseases: 219; N. variants: 15
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.030 AlteredExpression disease BEFREE Mouse DLL4 or JAG1 expressed in glioblastoma cells decreased tumour cell proliferation in vitro but promoted tumour growth in vivo. mDLL4-expressing tumours showed fewer but larger vessels whereas mJAG1-tumours produced more vessels. 28445154 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.030 AlteredExpression disease BEFREE Dll4 expression was localized to the cytoplasm and membrane of endothelial cells in all glioblastomas; it was weak or absent in normal brain. 22296176 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.030 AlteredExpression disease BEFREE Here, we show that DLL4, when expressed in tumor cells, functions as a negative regulator of tumor angiogenesis by reducing the number of blood vessels in all five types of xenografts, but acts as a positive driver for tumor growth in two of them (human glioblastoma and prostate cancer). 18056450 2007