|
Germ cell tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OCT4 is expressed in germ cell tumors but also aberrantly in cancers developing in differentiated tissues.
|
28911263 |
2017 |
|
Germ cell tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In recent years, many researches have shown that OCT4 is overexpressed in both germ cell tumors and somatic cancers.
|
26152287 |
2015 |
|
Germ cell tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OCT4 and SALL4 can be used with caution as second-tier normalizers when determining changes in gene expression in germ cells and germ cell tumour components, but the relative transcript abundance appears variable between different germ cell tumour types.
|
24743772 |
2014 |
|
Germ cell tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4.
|
23302226 |
2013 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although OCT-4 has been introduced as a molecular marker for germ cell tumors, little is known about its expression in somatic cancers.
|
17205510 |
2007 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, the findings argue against OCT3/4 being a driving oncogenic factor in the pathogenesis of human germ cell tumors.
|
17549357 |
2007 |
|
Germ cell tumor
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aberrant expression and distribution of the OCT-4 transcription factor in seminomas may provide some important clues concerning the cell transformation between germ line stem cells (like PGC) and testicular germ cell tumors.
|
17682839 |
2007 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
TSPY protein localized with established germ cell tumor markers, such as the placental alkaline phosphatase, c-KIT, and OCT3/4, in the same tumor cells of both gonadoblastoma and adjacent carcinoma in situ, the precursor for germ cell tumors.
|
17349529 |
2007 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
The abundance of factors associated with pluripotency (NANOG and OCT-3/4) and undifferentiated state (AP-2gamma) may explain the remarkable pluripotency of germ cell neoplasms, which are capable of differentiating to various somatic tissue components of teratomas.
|
16540528 |
2006 |
|
Germ cell tumor
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, major progress has been made in identifying gene-products related to germ cell tumor development (testis-specific protein-Y encoded and octamer binding transcription factor 3/4) and in recognizing early changes of germ cells (maturation delay, preneoplastic lesions, and in situ neoplasia).
|
16735607 |
2006 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this issue of Cancer Cell, Gidekel et al. demonstrate that Oct-4, a member of the POU class of homeobox genes, is a critical player in the genesis of testicular germ cell tumors.
|
14667497 |
2003 |
|
Germ cell tumor
|
0.400 |
Biomarker
|
disease |
BEFREE |
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.
|
12727846 |
2003 |
|
Embryonal Neoplasm
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated expression and prognostic value of the neural stem cell marker CD133, as well as of the pluripotency genes LIN28 and OCT4 in 37 samples of pediatric medulloblastoma, the most common and challenging type of embryonal tumor.
|
21725800 |
2012 |
|
Embryonal Neoplasm
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development.
|
18467432 |
2008 |
|
Embryonal Neoplasm
|
0.330 |
Biomarker
|
disease |
BEFREE |
At the protein level, expression of the immunohistochemical markers cytokeratins (pan-cytokeratin staining), placental-like alkaline phosphatase, anti-cytokeratin clone 5.2, CD30, anion exchanger 1/3, junction plakoglobulin (JUP), and POU domain, class 5, transcription factor 1 (octomer-binding transcription factor 3/4) was significantly different between seminomas and embryonal tumors.
|
16115909 |
2005 |
|
Embryonal Neoplasm
|
0.330 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Ovarian Failure, Premature
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
The results show that the activity of Hh signaling is decreased in the ovaries in physiological aging and POF models, which is consistent with the trend of expression levels of the germline stem cell markers Mvh and Oct4.
|
31277696 |
2019 |
|
Germ Cell Cancer
|
0.320 |
Biomarker
|
disease |
BEFREE |
Gonadal biopsy is in some cases the best procedure of choice to assess the risk, and with the availability of immunohistochemical biomarkers [OCT3/4 (POU5F1), TSPY, SOX9, FOXL2 and KITLG (SCF)], a reliable classification of GCC and its precursors can be made.
|
29131109 |
2018 |
|
Gestational trophoblastic disease
|
0.320 |
Biomarker
|
disease |
BEFREE |
In summary, we provide evidence of the presence of NANOG+/OCT-4+/SOX2+ trophoblastic SLCs that are capable to contribute to the susceptibility to GTD and that may be involved in Chemoresistance associated with drug resistance and recurrence in high risk GTDs' patients.
|
29467949 |
2018 |
|
Ovarian Failure, Premature
|
0.320 |
Biomarker
|
disease |
BEFREE |
As far as is known, the present study is the first to identify a potential association between POU5F1 and the development of POF.
|
21273125 |
2011 |
|
Ovarian Failure, Premature
|
0.320 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
As far as is known, the present study is the first to identify a potential association between POU5F1 and the development of POF.
|
21273125 |
2011 |
|
Germ Cell Cancer
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
This study investigates expression of the various OCT3/4 isoforms in GCTs (both differentiated and undifferentiated) and somatic (non-germ cell) cancers, including representative cell lines and xenografts.
|
21847120 |
2011 |
|
Gestational trophoblastic disease
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that Oct4 is down-regulated by hypermethylation in normal placenta and GTD and such process is important in pathogenesis of GTD.
|
18440631 |
2008 |
|
Gestational trophoblastic disease
|
0.320 |
Biomarker
|
disease |
CTD_human |
Our findings suggest that Oct4 is down-regulated by hypermethylation in normal placenta and GTD and such process is important in pathogenesis of GTD.
|
18440631 |
2008 |