|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
This same risk allele at ARL15 was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5x10(-6), n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2x10(-3), n = 10,128), and several metabolic traits.
|
20011104 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that population structure analysis displayed no differences between T2D patients and healthy individuals; 24 loci located were identified for probable association with T2D (p > 1.288 × 10<sup>-7</sup> and p < 1.348 × 10<sup>-4</sup>); the polymorphism AGTR2 rs1914711 in chromosome X was identified by the allele test (OR = 6.824; p = 1.448 × 10<sup>-9</sup>) as a candidate gene for association with T2D; and ARL15 rs4311394 was associated as a T2D protector by genotype and the Armitage trend test (OR = 0.318; p = 0.001).
|
30130595 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1, POU5F1, ARL15, and MPHOSPH9) originally identified by a transethnic meta-analysis of genome-wide association studies (GWAS) in 2014.
|
27115357 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Recently, genomic studies have found that ARL15, and some of its common genetic variants are associated with type 2 diabetes and coronary atherosclerosis.
|
30682341 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
24962325 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We also identified intronic SNPs in the ADP-ribosylation factor like 15 (ARL15) gene on chromosome 5 (P=1.11×10(-8)) and the UTP20 small subunit (UTP20) gene on chromosome 12 (P=4.32×10(-8)) that were associated with age at onset of AD.
|
24962325 |
2014 |
|
Coronary Artery Disease
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of ARL15 or ARF family genes in RA aetiology remains unknown.
|
29465355 |
2018 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition to the expected association of the HLA locus with RA, we identified association with a novel intronic SNP of ARL15 (rs255758) on chromosome 5 (Pcombined = 6.57 × 10(-6); odds ratio 1.42).
|
23918589 |
2013 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, genomic studies have found that ARL15, and some of its common genetic variants are associated with type 2 diabetes and coronary atherosclerosis.
|
30682341 |
2019 |
|
Coronary Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Coronary heart disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.
|
20011104 |
2009 |
|
Coronary heart disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Metabolic Syndrome X
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology.
|
29465355 |
2018 |
|
Metabolic Syndrome X
|
0.020 |
Biomarker
|
disease |
BEFREE |
The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
|
29242557 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, genomic analyses have identified ARL15 as a new candidate gene related to diabetes.
|
28322786 |
2017 |
|
Lipodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings provide evidence that ARL15 plays a role in adipocyte differentiation and adiponectin secretion, and raise the possibility that human ARL15 haploinsufficiency predisposes to lipodystrophy.
|
29242557 |
2017 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Proteins involved in inflammation (fibrinogen alpha (FIBA), serotransferrin (TRFE, and kininogen-1 (KNG1)) and insulin resistance (ADP-ribosylation factor (ARF)-like protein 15 (ARL15) and retinol-binding protein 4 (RET4)) were found to be significantly increased in the urine samples of MUHO compared to MHO patients.
|
31623319 |
2019 |
|
Albuminuria
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure.
|
30220432 |
2018 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |