|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
This same risk allele at ARL15 was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5x10(-6), n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2x10(-3), n = 10,128), and several metabolic traits.
|
20011104 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that population structure analysis displayed no differences between T2D patients and healthy individuals; 24 loci located were identified for probable association with T2D (p > 1.288 × 10<sup>-7</sup> and p < 1.348 × 10<sup>-4</sup>); the polymorphism AGTR2 rs1914711 in chromosome X was identified by the allele test (OR = 6.824; p = 1.448 × 10<sup>-9</sup>) as a candidate gene for association with T2D; and ARL15 rs4311394 was associated as a T2D protector by genotype and the Armitage trend test (OR = 0.318; p = 0.001).
|
30130595 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1, POU5F1, ARL15, and MPHOSPH9) originally identified by a transethnic meta-analysis of genome-wide association studies (GWAS) in 2014.
|
27115357 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Recently, genomic studies have found that ARL15, and some of its common genetic variants are associated with type 2 diabetes and coronary atherosclerosis.
|
30682341 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We also identified intronic SNPs in the ADP-ribosylation factor like 15 (ARL15) gene on chromosome 5 (P=1.11×10(-8)) and the UTP20 small subunit (UTP20) gene on chromosome 12 (P=4.32×10(-8)) that were associated with age at onset of AD.
|
24962325 |
2014 |
|
Coronary Artery Disease
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of ARL15 or ARF family genes in RA aetiology remains unknown.
|
29465355 |
2018 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition to the expected association of the HLA locus with RA, we identified association with a novel intronic SNP of ARL15 (rs255758) on chromosome 5 (Pcombined = 6.57 × 10(-6); odds ratio 1.42).
|
23918589 |
2013 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, genomic studies have found that ARL15, and some of its common genetic variants are associated with type 2 diabetes and coronary atherosclerosis.
|
30682341 |
2019 |
|
Coronary Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Coronary heart disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.
|
20011104 |
2009 |
|
Coronary heart disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Metabolic Syndrome X
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology.
|
29465355 |
2018 |
|
Metabolic Syndrome X
|
0.020 |
Biomarker
|
disease |
BEFREE |
The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
|
29242557 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, genomic analyses have identified ARL15 as a new candidate gene related to diabetes.
|
28322786 |
2017 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Recently, genomic analyses have identified ARL15 as a new candidate gene related to diabetes.
|
28322786 |
2017 |
|
Lipodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings provide evidence that ARL15 plays a role in adipocyte differentiation and adiponectin secretion, and raise the possibility that human ARL15 haploinsufficiency predisposes to lipodystrophy.
|
29242557 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Cross species comparative analysis with aCGH data of human cancer cell lines revealed known and candidate oncogenes (Mmp13, Slamf6, and Rreb1) and tumor suppressors (Wwox and Arfrp2).
|
18485879 |
2008 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Proteins involved in inflammation (fibrinogen alpha (FIBA), serotransferrin (TRFE, and kininogen-1 (KNG1)) and insulin resistance (ADP-ribosylation factor (ARF)-like protein 15 (ARL15) and retinol-binding protein 4 (RET4)) were found to be significantly increased in the urine samples of MUHO compared to MHO patients.
|
31623319 |
2019 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Since, the function of ARL15 is unclear we aimed at investigating the role of ARL15 in ED induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs).
|
30682341 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The effect of ARL15 on the expression of adiponectin, adiponectin receptor I, IL6 and GAPDH and on cell mobility by invasion and migration assays were assessed by siRNA mediated gene knockdown.
|
29465355 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
24962325 |
2014 |