|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.
|
11089532 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is concluded that combined DHA-T<sub>3</sub> supplementation achieves synergistic effects on liver PPARα-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders.
|
28990606 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, understanding the ties between PPAR- γand Wnt signaling in MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
|
29034841 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both PPARα and GPR119 have potential as pharmacological targets for the treatment of obesity and the former for treatment of intestinal inflammation.
|
29473944 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate whether HAART induces vascular dysfunction in obesity and to explore the underlying mechanisms of PPARα/γ stimulation, male Wistar rats were placed on a high-calorie diet for 16 weeks.
|
31284000 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor (PPAR) gene plays an important role in obesity and PPAR δ protein is a potent inhibitor; however, few previous studies have focused on this gene.
|
26073637 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Estrogen inhibits the actions of PPARalpha on obesity and lipid metabolism through its effects on PPARalpha-dependent regulation of target genes.
|
19646654 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fatty acid administration, and PPARα and PPARδ (PPARα/δ) agonists, mimicked obesity and inhibited mechanistic target of rapamycin (mTOR)-mediated glycolysis.
|
30420624 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, this study aimed to determine whether ascorbic acid can inhibit obesity and nonalcoholic fatty liver disease (NAFLD) in part through the actions of PPARα.
|
30283077 |
2019 |
|
Obesity
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that GSK-3α promotes lipid anabolism through PPARα-Ser280 phosphorylation, which underlies the development of lipotoxic cardiomyopathy in the context of obesity.
|
30745182 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
|
20444420 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5).
|
24814977 |
2014 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced DNA methylation is associated with enhanced induction of hepatic FGF21 expression after PPARα activation, which may partly explain the attenuation of diet-induced obesity in adulthood.
|
29434210 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to evaluate the differences in the expression of PPARα target genes in human peripheral blood mononuclear cells (PBMCs) and free fatty acids (FFA) in obese and non-obese individuals after 24 h of fasting.
|
25500634 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the enhanced expression of obesity-related proteins (PPAR[Formula: see text], C/EBP[Formula: see text], SREBP-1c, and FAS) in MDI medium-cultivated 3T3-L1 cells was significantly attenuated by the addition of cinnamyl alcohol at 5[Formula: see text][Formula: see text]g/mL and 10[Formula: see text][Formula: see text]g/mL.
|
28490236 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, the PPAR-γ2-RXR-α heterodimer showed weak activity and bound weakly to the putative IGFBP-2-PPRE promoter sequence in VAT from HIR-MO subjects when compared with LIR-MO individuals.
|
31547433 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because PPARA plays a central role in fatty acid homeostasis, and in the transcriptional regulation of genes that are necessary for maintenance of the redox balance during the oxidative catabolism of fatty acids, we suggest that PPARA loss and miR-519d overexpression could be associated with metabolic imbalance and subsequent adipocyte hypertrophy in SAT during obesity.
|
20057369 |
2010 |