Disease: Age related macular degeneration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 Biomarker disease BEFREE Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. 29628329 2018
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 Biomarker disease BEFREE We also suggest PPARα as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits. 29183319 2017
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 Biomarker disease BEFREE Feno-FA has therapeutic effects on ocular NV in models recapitulating neovascular AMD through a PPARα-dependent mechanism. 28980001 2017
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.040 AlteredExpression disease BEFREE A disease associated SNP-to gene-to target-to ligand approach provided guidance to inform preventive and therapeutic preclinical studies investigating roles of targets in: 1) PPAR-RXR transcription complex constituents for neovascular AMD; and 2) the stress activated MAPK signaling cascade constituents for advanced AMD. 25109799 2014