Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor γ (PPAR-γ) activators display anti-inflammatory and anti-degeneration roles in osteoarthritis and rheumatoid arthritis.
|
30981079 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further, 5Aza-confered protections against the cartilage damage and the associated abnormalities of OA-susceptible factors were significantly abrogated in PPARγ knockout mice.
|
31239244 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings indicate AGEs induce an inflammatory response in human articular chondrocytes via the PPARγ/AMPK/SIRT-1 pathway, which is therefore a potential target in OA therapy.
|
31366866 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARγ), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4).
|
29976400 |
2018 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data also suggest that PPARγ participates in oxidation and anti-oxidation of OA.
|
29673954 |
2018 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes.
|
27734234 |
2017 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that both acute and chronic OA treatments reduced serum levels of triglycerides, total cholesterol, and LDL cholesterol, and decreased hepatic expression levels of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β), which is an important regulator in maintaining hepatic lipid homeostasis, and its downstream target genes.
|
27903618 |
2017 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Betulinic acid inhibits IL-1β-induced inflammation by activating PPAR-γ in human osteoarthritis chondrocytes.
|
26391061 |
2015 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results showed that TNFAIP3, ATF3, PPARG, etc, have related with osteoarthritis.
|
23884832 |
2013 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis.
|
22840054 |
2012 |
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, the role of PPARγ polymorphism in the pathogenesis of OA and related musculoskeletal diseases will also be discussed.
|
20820843 |
2011 |
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity.
|
17568789 |
2007 |
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genotype and allele frequencies for either polymorphism in the PPARgamma gene did not differ significantly between patients with osteoarthritis and controls.
|
16973789 |
2006 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PPARalpha and PPARgamma messenger RNA (mRNA) expression and protein synthesis in OA HSFs were measured by reverse transcription-polymerase chain reaction and electrophoretic mobility shift assay, respectively.
|
11840453 |
2002 |