TET2, tet methylcytosine dioxygenase 2, 54790

N. diseases: 362; N. variants: 47
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 PosttranslationalModification disease BEFREE Taken together, we demonstrate for the first time that TET2 is a direct repression target of KDM2A and reveal a novel mechanism by which KDM2A promotes DNA methylation and breast cancer progression via the inhibition of a DNA demethylase. 28785073 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 AlteredExpression disease BEFREE Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway. 28218902 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 GeneticVariation disease BEFREE Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 downregulation has been shown to promote malignancy in breast cancer. 25362856 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 Biomarker disease BEFREE We investigated the impact of 5 mC, 5 hmC, TET1, and TET2 on tumorigenesis and prognosis of breast cancer. 26253945 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 Biomarker disease BEFREE Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. 26354892 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 GeneticVariation disease GWASCAT Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. 25751625 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.150 GeneticVariation disease GWASCAT Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 23535729 2013