MOCOS, molybdenum cofactor sulfurase, 55034

N. diseases: 81; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Outcomes included health-related quality of life as measured by the short-form 12-item interview (SF-12) physical and mental component summary (PCS and MCS) scores, depression, post-traumatic stress disorder (PTSD), eating disorders, fibromyalgia, other chronic pain, cardiovascular disease risk factors, and cancer. 31755818 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE In cluster 3 (52 patients) we found a reduction of MCS and increase of depression and fatigue (similar to cluster 2) but also a decrease in PCS levels and Bodily Pain (meaning increase in pain). 31140392 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 GeneticVariation disease BEFREE Baseline scores were compared to post-injury time points for SF-12 subscores (physical and mental; PCS-12, MCS-12) and HADS subscores (depression and anxiety; HADS-D, HADS-A). 30302664 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE The results showed acceptance of illness to be positively correlated with quality of life in terms of PCS (rho = 0.43) and MCS (rho = 0.36), and depression and anxiety to be negatively correlated with quality of life in both domains (PCS: rho = -0.39 and rho = -0.56, respectively; MCS: rho = -0.56 and rho = -0.78, respectively). 31070268 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Multiple regression analysis detected the General Fatigue score of the MFI-20 questionnaire and depression identified by the PHQ-9 score as independent variables predicting MCS of the SF-36 in both genders. 30587146 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases. 29680420 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Hierarchical analyses showed that after controlling for potential confounding factors (demographics, depression, BMI), sleep quality significantly increased model's predictive power with an R² change (ΔR²) by 3.5% for PCS (adjusted R² = 0.27) and by 2.9% for MCS (adjusted R² = 0.48); for the other SF-12 components ΔR² ranged between 1.4% and 4.6%. 30049991 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Given the great variability of depressive symptoms in patients with or without self-reported depression and medicated or unmedicated status, we elected to use the MCS classification of depressive symptoms for our analysis. 29620945 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Importantly, earlier MCS and PCS were both negatively associated with downstream symptoms of mania and depression. 28918761 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE MCS-12 was negatively associated with being female, living alone, insufficient disease control, and reporting symptoms of anxiety or depression. 27624747 2017