Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Arginine vasopressin (AVP) may be a factor in inflammation and fibrosis in the pathogenesis of heart failure.
|
31515529 |
2020 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Arginine vasopressin antagonism in heart failure: Current status and possible new directions.
|
30904236 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HF rats showed higher plasma concentration of NT-proBNP and copeptin.
|
31645268 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evidence is accumulating that increased osmolarity, AVP, copeptin, and dehydration are all associated with worse outcomes in chronic disease states such as chronic kidney disease (CKD), diabetes, and heart failure.
|
31365096 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Copeptin remained as a predictor at discharge and after 3 months in the final multiple model (including: heart failure/age/creatinine clearance).
|
30309264 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
After adjusting for confounders, high-copeptin was still an independent predictor for all-cause death/HF [hazard ratio (95% confidence interval): 1.77 (1.04-3.01), p=0.03].
|
30591319 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
The AVP system might be one of the mechanisms linking heart failure and the onset of type 2 diabetes mellitus in adults with CHD.
|
30460574 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Copeptin - the C-terminal section of vasopressin precursor - is a novel biomarker, that has been shown to be a useful prognostic factor in heart failure, ischemic stroke and in acute myocardial infarction (MI) but with restricted population and follow-up in ST-segment elevation MI (STEMI) setting.
|
30217427 |
2019 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
We would like to comment on the article entitled "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues, in the light of the results of a multicentric study published in 2014 by Vetrone F. et al., in which 336 patients with dyspnea were enrolled in the Emergency Departments of three University Hospitals in Italy.These two studies confirm the prognostic role of copeptin in patients with dyspnea due to heart failure but, while Winther et al. performed the copeptin measurements only at admission, Vetrone et al. evaluated the time-course of copeptin plasma concentration from the admission to the hospital discharge.
|
29490639 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing β-blocker uptitration in elderly patients with heart failure.
|
30450925 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Arginine vasopressin levels were significantly greater in HFpEF [0.96 pg/mL; 95% confidence interval (CI) = 0.83-1.1 pg/mL] compared with subjects without HF (0.69 pg/mL; 95% CI = 0.6-0.77 pg/mL; P = 0.0002).
|
29969536 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Copeptin levels and invasive hemodynamics in patients with advanced heart failure.
|
30058349 |
2018 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that copeptin is an important marker in CKD, but not so concerning heart failure in the disease.
|
29572679 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The clinical application value of the plasma copeptin level in the assessment of heart failure with reduced left ventricular ejection fraction: A cross-sectional study.
|
30278578 |
2018 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Severe mitral regurgitation is associated with increased copeptin levels in heart failure with reduced ejection fraction.
|
28715068 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of arginine vasopressin (AVP) are closely associated with the progression of heart failure and could be an underlying cause of cardiac fibrosis.
|
27862165 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Relationship and mechanism of Kv2.1 expression to ADH secretion in rats with heart failure.
|
28861159 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Enhanced copeptin levels (reflecting enhanced vasopressin levels) in 25% of the common population are associated with enhanced risk of metabolic syndrome with abdominal obesity, type 2 diabetes, hypertension, coronary artery disease, heart failure, vascular dementia, cognitive impairment, microalbuminuria, chronic kidney disease, inflammatory bowel disease, cancer, and premature mortality.
|
28787716 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For all-cause mortality of patients with HF, we also found a significant association between elevated plasma copeptin level and increased mortality of HF (HR, 1.76; 95% CI, 1.33-2.33).
|
28244638 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In multivariable logistic regression analysis, copeptin and NT-proBNP levels remained as independent predictors of heart failure (P < 0.01 for both) and adverse cardiac events (P < 0.01 for both).
|
27768229 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pooled SMD showed that copeptin levels were significantly higher in patients with HF who died during the follow-up period than in survivors (SMD =1.19, 95% CI =0.81-1.57).
|
28115852 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, copeptin has been shown to be associated with increased risk of complications such as myocardial infarction, heart failure, diabetes mellitus and metabolic syndrome.
|
28714397 |
2017 |
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, elevated natriuretic peptides, ST2, endothelin-1, mid-regional-pro-adrenomedullin, copeptin, and galectin-3 have all been well validated to predict death and heart failure following a MI and provide risk stratification information for heart failure.
|
28491088 |
2017 |
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An elevated copeptin level was associated with an increased risk of all-cause mortality in HF patients (Relative risk (RR) was 2.64 (95% CI, 2.09-3.32)).
|
28982590 |
2017 |
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
NT-proBNP levels are superior to copeptin levels to diagnose acute HF in patients with acute dyspnea.
|
29100503 |
2017 |