CASC1, cancer susceptibility 1, 55259

N. diseases: 16; N. variants: 3
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.340 Biomarker group BEFREE CASC1, which is frequently co-amplified with KRAS in lung tumors, is essential for microtubule polymerization and satisfaction of the spindle assembly checkpoint. 24860162 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.340 GeneticVariation group BEFREE Mouse Lrmp and Casc1 genes are candidates for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumor susceptibility. 16410263 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.340 Biomarker group BEFREE Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors. 16862160 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.340 Biomarker group CTD_human In (A/J x C57BL/6J)F1 mouse lung tumors, the Lmna-rs1 gene was completely downregulated, whereas allele-specific downregulation of the C57BL/6J-derived allele was observed at the Las1 gene, suggesting the potential role of these genes in tumor suppression. 15064703 2004
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.340 Biomarker group BEFREE Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity. 14583591 2003