AVPR1B, arginine vasopressin receptor 1B, 553

N. diseases: 29; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE To investigate the role of the pituitary vasopressin (V3) receptor (R) in ACTH-secreting tumours we have qualitatively and quantitatively analysed its mRNA. 9876345 1998
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 Biomarker group PSYGENET We examined whether genetic variations in the AVP receptor 1b gene (AVPR1b) could be associated with increased susceptibility to affective disorders using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). 15094789 2004
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 GeneticVariation group BEFREE We examined whether genetic variations in the AVP receptor 1b gene (AVPR1b) could be associated with increased susceptibility to affective disorders using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). 15094789 2004
CUI: C0154409
Disease: Recurrent major depressive episodes
Recurrent major depressive episodes 		0.010 GeneticVariation disease BEFREE Five SNPs were identified in AVPR1b and genotyped in two well-diagnosed samples of patients with recurrent major depression and matched controls. 15094789 2004
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.010 Biomarker disease BEFREE The occurrence of the V1bR/V3R is of 28 and 18% for SCLC and NSCLC, respectively. 16043261 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 GeneticVariation group BEFREE We genotyped single nucleotide polymorphisms (SNPs) across the AVPR1B gene in a family-based sample with childhood-onset mood disorders. 17909131 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 Biomarker group PSYGENET We genotyped single nucleotide polymorphisms (SNPs) across the AVPR1B gene in a family-based sample with childhood-onset mood disorders. 17909131 2007
CUI: C0221406
Disease: Pituitary-dependent Cushing's disease
Pituitary-dependent Cushing's disease 		0.020 AlteredExpression disease BEFREE CRHR, V1bR, and 11beta-HSD2 mRNA levels in CD were greater than those in SCA and NFT. 18057378 2007
CUI: C0018790
Disease: Cardiac Arrest
Cardiac Arrest 		0.010 AlteredExpression disease BEFREE CRHR, V1bR, and 11beta-HSD2 mRNA levels in CD were greater than those in SCA and NFT. 18057378 2007
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.010 GeneticVariation disease BEFREE These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder. 18384079 2008
CUI: C0001231
Disease: ACTH Syndrome, Ectopic
ACTH Syndrome, Ectopic 		0.010 AlteredExpression disease BEFREE Higher expression of AVPR1B was observed in the EAS patients responsive to desmopressin, as well as in corticotrophic tumors, as compared with normal pituitary samples, but no correlation between AVPR1B expression and response to desmopressin was observed in the CD patients. 18426818 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.220 Biomarker group BEFREE The vasopressin receptor type 1b (AVPR1B) is mainly expressed by pituitary corticotropes and it mediates the stimulatory effects of AVP on ACTH release; common AVPR1B haplotypes have been involved in mood and anxiety disorders in humans, while rodents lacking a functional receptor gene display behavioral defects and altered stress responses. 19486526 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.200 Biomarker disease RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C0236664
Disease: Alcohol-Related Disorders
Alcohol-Related Disorders 		0.200 Biomarker group RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C0236970
Disease: Alcohol-Induced Disorders
Alcohol-Induced Disorders 		0.200 Biomarker group RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C2751719
Disease: ALCOHOL DEPENDENCE, PROTECTION AGAINST
ALCOHOL DEPENDENCE, PROTECTION AGAINST 		0.200 Biomarker phenotype RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C3887915
Disease: AERODIGESTIVE TRACT CANCER, SQUAMOUS CELL, ALCOHOL-RELATED, PROTECTION AGAINST
AERODIGESTIVE TRACT CANCER, SQUAMOUS CELL, ALCOHOL-RELATED, PROTECTION AGAINST 		0.200 Biomarker phenotype RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE This study was attempted to determine the gene expression profiles of transcription factors (Tpit, NeuroD1 and IKZF1), proprotein convertase (PC) 1/3 and PC2, and several key receptors linked to ACTH secretion, including corticotrophin releasing hormone receptor (CRHR1), vasopressin receptor 1b (V1bR), somatostatin receptor (SSTR) subtype-2, -5 and dopamine receptor type 2 (D2R) in non-pituitary and pituitary ACTH-secreting tumors. 21383526 2011
CUI: C0032002
Disease: Pituitary Diseases
Pituitary Diseases 		0.020 Biomarker group BEFREE This study was attempted to determine the gene expression profiles of transcription factors (Tpit, NeuroD1 and IKZF1), proprotein convertase (PC) 1/3 and PC2, and several key receptors linked to ACTH secretion, including corticotrophin releasing hormone receptor (CRHR1), vasopressin receptor 1b (V1bR), somatostatin receptor (SSTR) subtype-2, -5 and dopamine receptor type 2 (D2R) in non-pituitary and pituitary ACTH-secreting tumors. 21383526 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features. 22341483 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features. 22341483 2012
CUI: C0025193
Disease: Melancholia
Melancholia 		0.010 GeneticVariation disease BEFREE No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder. 23068076 2013
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.220 GeneticVariation group BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.210 GeneticVariation disease BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0003467
Disease: Anxiety
Anxiety 		0.010 GeneticVariation disease BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013