RNLS, renalase, FAD dependent amine oxidase, 55328

N. diseases: 32; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.300 Biomarker disease CTD_human Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
CUI: C4722327
Disease: PROSTATE CANCER, HEREDITARY, 1
PROSTATE CANCER, HEREDITARY, 1 		0.300 Biomarker disease CTD_human Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.210 GeneticVariation disease BEFREE Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension. 21617193 2012
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.210 Biomarker disease RGD Catecholamines regulate the activity, secretion, and synthesis of renalase. 18299506 2008
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.200 Biomarker disease RGD Lisinopril protects against the adriamycin nephropathy and reverses the renalase reduction: potential role of renalase in adriamycin nephropathy. 24022426 2013
CUI: C0027707
Disease: Nephritis, Interstitial
Nephritis, Interstitial 		0.200 Biomarker disease RGD Lisinopril protects against the adriamycin nephropathy and reverses the renalase reduction: potential role of renalase in adriamycin nephropathy. 24022426 2013
CUI: C0178664
Disease: Glomerulosclerosis (disorder)
Glomerulosclerosis (disorder) 		0.200 Biomarker disease RGD Lisinopril protects against the adriamycin nephropathy and reverses the renalase reduction: potential role of renalase in adriamycin nephropathy. 24022426 2013
CUI: C0018801
Disease: Heart failure
Heart failure 		0.200 Biomarker disease RGD Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. 21297953 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.200 Biomarker disease RGD Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. 21297953 2011
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.120 GeneticVariation disease GWASCAT Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. 25751624 2015
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.120 GeneticVariation disease BEFREE Lastly, we will discuss the association of certain single nucleotide polymorphisms in the renalase gene with type 1 diabetes and with ischemic stroke, and the clinical implications of these findings. 24992568 2014
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.120 GeneticVariation disease BEFREE The alleles that confer susceptibility to type 1 diabetes at interleukin-2 (IL-2), IL2/4q27 (rs2069763) and renalase, FAD-dependent amine oxidase (RNLS)/10q23.31 (rs10509540), were associated with a lower age-at-diagnosis (P = 4.6 × 10⁻⁶ and 2.5 × 10⁻⁵, respectively). 22891215 2012
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0014772
Disease: Red Blood Cell Count measurement
Red Blood Cell Count measurement 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.100 GeneticVariation disease GWASCAT Genome-wide association study of familial lung cancer. 29924316 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.100 GeneticVariation disease GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.100 GeneticVariation disease GWASCAT Genetics of long-term treatment outcome in bipolar disorder. 26297903 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 GeneticVariation group BEFREE Renalase gene rs2296545 polymorphism is significantly associated with increased risk of HT, whereas rs2576178 polymorphism may not be associated with the susceptibility to HT. 27434211 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 GeneticVariation group BEFREE Renalase gene polymorphism in patients with hypertension and concomitant coronary heart disease. 24821235 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 GeneticVariation group BEFREE The aim of the study was to assess the relationship of two renalase gene polymorphisms with hypertension in dialysed patients. 21617193 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 GeneticVariation group BEFREE Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. 22812913 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 GeneticVariation group BEFREE In addition, polymorphisms of the renalase gene in hemodialysed patients were associated with hypertension. 22227817 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 GeneticVariation group BEFREE Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study was to investigate the involvement of renalase gene polymorphisms in hypertension in type 2 diabetes patients. 21964580 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 Biomarker group LHGDN Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population. 17216203 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.080 Biomarker group LHGDN Renalase, a new renal hormone: its role in health and disease. 17565281 2007