High STYK1 expression predicted worse OS and was related to high GPX4 in NSCLC tissues; overexpression of STYK1 in lung cancer cell line SW900 upregulated the expression of GPX4, promoted proliferation, and attenuated diverse mitochondrial abnormalities specific to ferroptosis, whereas knockdown of GPX4 exacerbated such attenuations without affecting cell proliferation.
In contrast, NOK mRNA was detected in 97.6% (40/41) of lung cancer tissues, resulting in a sensitivity of 80.5% and a specificity of 92.3% that was estimated using the cutoff obtained from receiver operating characteristic curve analysis.