Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE With peptide-coding capacity, circLgr4 drove the self-renewal of colorectal CSCs through peptide-dependent manner. circLgr4-derived peptide interacted with and activated Lgr4, which further promoted the activation of Wnt/β-catenin signaling. circLgr4-peptide-Lgr4 axis could be used to target colorectal CSCs and colorectal tumorigenesis. 31269234 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE The signaling pathway involving the R-spondins and its cognate receptor, GPR48/LGR4, is crucial in development and carcinogenesis. 29383135 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway. 27743893 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE Collectively, our findings identify Lgr4 as a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/β-catenin pathways. 27693558 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway. 25636507 2015