MIR449A, microRNA 449a, 554213

N. diseases: 89; N. variants: 2
Disease: Retinoblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.020 Biomarker disease BEFREE We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. 24120948 2013
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.020 Biomarker disease BEFREE We also reveal that miR-449a suppresses Rb phosphorylation through the knockdown of Cyclin D1 and previously validated target HDAC1. 20948989 2010