Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
One such agent is RITA (reactivation of p53 and induction of tumor cell apoptosis), which restores p53 expression in cells with hyperactive HDM2 and induces apoptosis.
|
31699971 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RITA, the RBP-J interacting and tubulin-associated protein, has been reported to be related to tumor development, but the underlying mechanisms are not understood.
|
31353815 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo administration of RITA or GANT61 suppressed rhabdomyosarcoma xenograft growth in nude mice; however, co-administration did not further enhance tumor suppression, even though cell proliferation was decreased.
|
30447254 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer.
|
29956735 |
2018 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Methylation of ZNF331 was significantly associated with tumor size, overall survival (OS), and disease-free survival (DFS) (<i>p</i> < 0.01, <i>p</i> < 0.01, <i>p</i> < 0.05).
|
29075358 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.
|
28427187 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A recent study demonstrated that small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53).
|
26134873 |
2015 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
One mutation, ZNF331 frameshift deletion, was detected only in the primary tumor.
|
26474454 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small molecule that induces a conformational change in p53, leading to activation of its downstream targets.
|
25119136 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our results suggest that ZNF331 possesses important functions for the suppression of gastric carcinogenesis as a novel functional tumor-suppressor gene.
|
22370639 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We evaluated whether the restoration of p53 function by the p53-reactivating small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (HNC).
|
22634494 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Accordingly, treatment of certain wild-type p53-expressing tumor cell lines with the p53-reactivating small molecular compound RITA resulted in upregulation of ULBP2 mRNA and cell surface protein expression.
|
21764762 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits hypoxia-inducible factor-1α and vascular endothelial growth factor expression in vivo and induces p53-dependent tumour cell apoptosis in normoxia and hypoxia.
|
21593792 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas.
|
20682794 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, RITA is a promising lead for the development of anti-cancer drugs that reactivate the tumor suppressor function of p53 in cancer cells irrespective whether they express mutant or wild type p53.
|
20436301 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PRIMA-1 (p53-dependent reactivation and induction of massive apoptosis) restores the wild-type conformation of mutant TP53, whereas RITA (reactivation of p53 and induction of tumour cell apoptosis) increases intracellular levels of p53.
|
18341636 |
2008 |