PREP, prolyl endopeptidase, 5550

N. diseases: 105; N. variants: 1
Disease: Neutrophilia (disorder) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3665444
Disease: Neutrophilia (disorder)
Neutrophilia (disorder) 		0.010 Biomarker disease BEFREE The neutrophil chemoattractant proline-glycine-proline (PGP) is generated from collagen by matrix metalloproteinase-8/9 (MMP-8/9) and prolyl endopeptidase (PE), and it is concomitantly degraded by extracellular leukotriene A4 hydrolase (LTA4H) to limit neutrophilia. 29202450 2017