PRF1, perforin 1, 5551

N. diseases: 163; N. variants: 31
Disease: Meningitis, Pneumococcal ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025295
Disease: Meningitis, Pneumococcal
Meningitis, Pneumococcal 		0.020 Biomarker disease BEFREE The cholesterol-dependent cytolysin pneumolysin and the bacterial capsule are key pathogenic factors, known to exacerbate the course of pneumococcal meningitis. 31103037 2019
CUI: C0025295
Disease: Meningitis, Pneumococcal
Meningitis, Pneumococcal 		0.020 AlteredExpression disease BEFREE A similar effect was observed in mice with pneumococcal meningitis only when the bacteria expressed the pore-forming cholesterol-dependent cytolysin pneumolysin. 23785278 2013