KLK15, kallikrein related peptidase 15, 55554

N. diseases: 28; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.320 GeneticVariation disease UNIPROT
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.190 AlteredExpression disease BEFREE KLK15 up-regulation was found to be associated with more aggressive forms of prostate cancer. 11010966 2001
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 AlteredExpression disease BEFREE KLK15 up-regulation was found to be associated with more aggressive forms of prostate cancer. 11010966 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE KLK15 expression tended to be higher in grade 3 than in grade 2 tumors and in Gleason score 7 or greater than in Gleason score less than 7 tumors (p = 0.18 and 0.23, respectively). 12478190 2003
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 AlteredExpression disease BEFREE KLK15 expression, as assessed by quantitative RT-PCR, is an independent marker of unfavorable prognosis for ovarian cancer. 12915603 2003
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.020 AlteredExpression disease BEFREE KLK15 expression, as assessed by quantitative RT-PCR, is an independent marker of unfavorable prognosis for ovarian cancer. 12915603 2003
CUI: C1853195
Disease: Prostate Cancer, Hereditary, 7
Prostate Cancer, Hereditary, 7
0.010 GeneticVariation disease BEFREE KLK15 SNP rs2659056 was found to be associated with prostate cancer aggressiveness and showed evidence of association in a replication cohort of 5,051 patients from the UK, Australia, and the CGEMS dataset of US samples. 22132073 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 GeneticVariation disease BEFREE A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival. 21457553 2011
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.020 GeneticVariation disease BEFREE A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival. 21457553 2011
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial
0.020 GeneticVariation disease BEFREE A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival. 21457553 2011
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.190 Biomarker disease BEFREE As KLK15 has mainly been associated with prostate cancer, we used a degradomic approach and subsequent KEGG pathway analysis to identify a number of putative protein substrates in the KLK15-treated prostate cancer cell line PC3. 29928903 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 Biomarker disease BEFREE As KLK15 has mainly been associated with prostate cancer, we used a degradomic approach and subsequent KEGG pathway analysis to identify a number of putative protein substrates in the KLK15-treated prostate cancer cell line PC3. 29928903 2018
CUI: C0043144
Disease: Wheezing
Wheezing
0.010 Biomarker phenotype BEFREE Further study of this instrument and wheeze in new samples of patients with ACO is warranted. 31151458 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE Furthermore, KLK15 transcripts were found to be highly expressed in more aggressive tumors (P = 0.017). 20067463 2010
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 Biomarker group BEFREE Furthermore, the D-ACO algorithm is tested using benchmark CKD dataset and the performance are investigated based on different evaluation factors. 31270387 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.010 GeneticVariation disease BEFREE Genetic analyses showed that IDH genes (IDH1, IDH2, IDH3A, IDH3B) and ACO genes (ACO1, ACO2) were not associated with BD. 26782057 2016
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions
0.010 GeneticVariation disease BEFREE High-risk patients, with high utilisation and multiple chronic illnesses, were identified in the Medicaid ACO population managed by the UofU Health plans for IOC eligibility. 30782742 2019
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate
0.010 AlteredExpression disease BEFREE Immunohistochemical expression of the KLK15 protein in 193 samples of prostatic adenocarcinoma was analysed in relation to clinicopathological parameters of the patients and disease progression. 20473923 2010
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.190 Biomarker disease BEFREE In search of biomarkers for prostate cancer, we evaluated the expression of the human kallikrein-related peptidase KLK15 in samples of prostatic adenocarcinomas from radical prostatectomies. 20473923 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 Biomarker disease BEFREE In search of biomarkers for prostate cancer, we evaluated the expression of the human kallikrein-related peptidase KLK15 in samples of prostatic adenocarcinomas from radical prostatectomies. 20473923 2010
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 Biomarker group BEFREE In search of biomarkers for prostate cancer, we evaluated the expression of the human kallikrein-related peptidase KLK15 in samples of prostatic adenocarcinomas from radical prostatectomies. 20473923 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 Biomarker group BEFREE In the past 5 years, the newly discovered kallikreins (KLK4-KLK15) have been associated with several types of cancer. 15911097 2005
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 Biomarker group BEFREE In the past 5 years, the newly discovered kallikreins (KLK4-KLK15) have been associated with several types of cancer. 15911097 2005
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 Biomarker group BEFREE Like other kallikreins, KLK15 is regulated by steroid hormones in cancer cell lines. 12915603 2003
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 Biomarker group BEFREE Like other kallikreins, KLK15 is regulated by steroid hormones in cancer cell lines. 12915603 2003