|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence suggest that members of the kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14).
|
12633763 |
2003 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer.
|
12439720 |
2002 |
|
Malignant neoplasm of breast
|
0.320 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of prostate
|
0.190 |
Biomarker
|
disease |
BEFREE |
As KLK15 has mainly been associated with prostate cancer, we used a degradomic approach and subsequent KEGG pathway analysis to identify a number of putative protein substrates in the KLK15-treated prostate cancer cell line PC3.
|
29928903 |
2018 |
|
Malignant neoplasm of prostate
|
0.190 |
Biomarker
|
disease |
BEFREE |
Previous studies implied a role of KLK15 in prostate cancer.
|
29958881 |
2018 |
|
Malignant neoplasm of prostate
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
Our aim in this present study was the specific quantitative expression analysis of the classical KLK15 mRNA transcript in prostate tumors and the examination of its clinical significance in prostate cancer.
|
23620432 |
2013 |
|
Malignant neoplasm of prostate
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
We performed a comprehensive analysis of association of variants in the KLK15 gene with prostate cancer risk and aggressiveness by genotyping tagSNPs, as well as putative functional SNPs identified by extensive bioinformatics analysis.
|
22132073 |
2011 |
|
Malignant neoplasm of prostate
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that KLK15 expression analysis could be employed as a valuable tool for the discrimination between BPH and CaP tissue specimens and as an unfavorable prognostic marker for prostate cancer.
|
20067463 |
2010 |
|
Malignant neoplasm of prostate
|
0.190 |
Biomarker
|
disease |
BEFREE |
In search of biomarkers for prostate cancer, we evaluated the expression of the human kallikrein-related peptidase KLK15 in samples of prostatic adenocarcinomas from radical prostatectomies.
|
20473923 |
2010 |
|
Malignant neoplasm of prostate
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
Malignant neoplasm of prostate
|
0.190 |
Biomarker
|
disease |
BEFREE |
The KLK15 splice variant appears to be a candidate biomarker for prostate cancer.
|
15650036 |
2005 |
|
Malignant neoplasm of prostate
|
0.190 |
Biomarker
|
disease |
BEFREE |
Up-regulation of the KLK15 gene in advanced and more aggressive tumors may indicate a possible role for KLK15 protein as future serum marker for prostate cancer and for distinguishing tumor aggressiveness.
|
12478190 |
2003 |
|
Malignant neoplasm of prostate
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
KLK15 up-regulation was found to be associated with more aggressive forms of prostate cancer.
|
11010966 |
2001 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Previous studies implied a role of KLK15 in prostate cancer.
|
29958881 |
2018 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
As KLK15 has mainly been associated with prostate cancer, we used a degradomic approach and subsequent KEGG pathway analysis to identify a number of putative protein substrates in the KLK15-treated prostate cancer cell line PC3.
|
29928903 |
2018 |
|
Prostate carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Our aim in this present study was the specific quantitative expression analysis of the classical KLK15 mRNA transcript in prostate tumors and the examination of its clinical significance in prostate cancer.
|
23620432 |
2013 |
|
Prostate carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We performed a comprehensive analysis of association of variants in the KLK15 gene with prostate cancer risk and aggressiveness by genotyping tagSNPs, as well as putative functional SNPs identified by extensive bioinformatics analysis.
|
22132073 |
2011 |
|
Prostate carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that KLK15 expression analysis could be employed as a valuable tool for the discrimination between BPH and CaP tissue specimens and as an unfavorable prognostic marker for prostate cancer.
|
20067463 |
2010 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
In search of biomarkers for prostate cancer, we evaluated the expression of the human kallikrein-related peptidase KLK15 in samples of prostatic adenocarcinomas from radical prostatectomies.
|
20473923 |
2010 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The KLK15 splice variant appears to be a candidate biomarker for prostate cancer.
|
15650036 |
2005 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Up-regulation of the KLK15 gene in advanced and more aggressive tumors may indicate a possible role for KLK15 protein as future serum marker for prostate cancer and for distinguishing tumor aggressiveness.
|
12478190 |
2003 |
|
Prostate carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
KLK15 up-regulation was found to be associated with more aggressive forms of prostate cancer.
|
11010966 |
2001 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We aimed to biochemically characterize KLK15 and preliminarily study its role in cancer.
|
29928903 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
We aimed to biochemically characterize KLK15 and preliminarily study its role in cancer.
|
29928903 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases.
|
23894413 |
2013 |