DOK4, docking protein 4, 55715

N. diseases: 8; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007124
Disease: Noninfiltrating Intraductal Carcinoma
Noninfiltrating Intraductal Carcinoma 		0.010 AlteredExpression disease BEFREE Knockdown of the putative oncogenic miRNA miR-182 and miR-183, both highly overexpressed in DCIS, increased the expression of chromobox homolog 7 (CBX7) (which regulates E-cadherin expression), DOK4, NMT2 and EGR1. 21375733 2011
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 Biomarker disease BEFREE In vitro cell culture studies demonstrate that treatment of NSCLC cell lines with the histone deacetylase inhibitor trichostatin A (TSA) upregulates IRS5/DOK4. 19073520 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.010 PosttranslationalModification group LHGDN Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. 19073520 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE This study examines the expression of IRS5/DOK4 in a panel of lung cancer cell lines and tumor specimens. 19073520 2008
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 AlteredExpression disease BEFREE This study examines the expression of IRS5/DOK4 in a panel of lung cancer cell lines and tumor specimens. 19073520 2008
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE This study examines the expression of IRS5/DOK4 in a panel of lung cancer cell lines and tumor specimens. 19073520 2008
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.010 AlteredExpression disease BEFREE DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma. 17443497 2007
CUI: C2931852
Disease: Clear-cell metastatic renal cell carcinoma
Clear-cell metastatic renal cell carcinoma 		0.010 AlteredExpression disease BEFREE The most striking finding is that expression of the new IRS family member IRS-5 is significantly upregulated in 90% of examined clear cell RCCs. 17443497 2007