TDP1, tyrosyl-DNA phosphodiesterase 1, 55775

N. diseases: 70; N. variants: 4
Disease: Leukopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023530
Disease: Leukopenia
Leukopenia 		0.020 GeneticVariation disease BEFREE A recent study found that variation in camptothecin pharmacodynamic genes (TOP1, PARP1, TDP1 and XRCC1) correlated with efficacy and risk of neutropenia in irinotecan-treated cancer patients (median dose: 180 mg/m2), which suggests that these genes might predict outcomes to irinotecan-based therapies. 19604089 2009
CUI: C0023530
Disease: Leukopenia
Leukopenia 		0.020 Biomarker disease BEFREE TOP1 and TDP1 htSNPs were related to grade 3/4 neutropenia (P = 0.04) and response (P = 0.04), respectively. 18347181 2008