PRKCB, protein kinase C beta, 5579

N. diseases: 317; N. variants: 18
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.240 AlteredExpression disease BEFREE Furthermore, we measured markedly increased total PKC and PKCα expression and PKCα-phosphorylation in HF. 29333637 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.240 AlteredExpression disease BEFREE Finally, PKC and non-muscle myosin are upregulated at the costameres in heart disease, indicating aberrant mechanosensing as a contributing factor to long-term remodeling and heart failure. 29396114 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.240 AlteredExpression disease BEFREE Proline-rich tyrosine kinase 2 (Pyk2) is a nonreceptor protein kinase regulated by intracellular Ca(2+), CaMK, and PKC and can be activated by different stress signals involved in heart failure. 21666110 2011
CUI: C0018801
Disease: Heart failure
Heart failure 		0.240 Biomarker disease RGD Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. 12392998 2002
CUI: C0018801
Disease: Heart failure
Heart failure 		0.240 Biomarker disease BEFREE Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. 11709417 2001